LGI1 encephalitis in childhood
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61988987%3A17110%2F23%3AA2402NEH" target="_blank" >RIV/61988987:17110/23:A2402NEH - isvavai.cz</a>
Result on the web
<a href="https://www.csnn.eu/en/journals/czech-and-slovak-neurology-and-neurosurgery/2023-3-9/lgi1-encephalitis-in-childhood-134908?hl=cs" target="_blank" >https://www.csnn.eu/en/journals/czech-and-slovak-neurology-and-neurosurgery/2023-3-9/lgi1-encephalitis-in-childhood-134908?hl=cs</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.48095/cccsnn2023208" target="_blank" >10.48095/cccsnn2023208</a>
Alternative languages
Result language
angličtina
Original language name
LGI1 encephalitis in childhood
Original language description
We present a case of a pediatric patient who developed autoimmune encephalitis with anti-LGI1 (leucine-rich glioma-inactivated 1) antibody positivity. She was a previously healthy 4-year-old girl admitted to the pediatric intensive care unit for cumulative left-sided predominant faciobrachial dystonic seizures (FBDS). The development of the difficulties was preceded by signs of febrile viral illness. Brain CT, lumbar puncture (LP) and neurological findings were negative. Meningeal syndrome and signs of intracranial hypertension were not expressed. The patient was treated with levetiracetam with beneficial effect. After 2 days, a recurrence of left-sided FBDS occurred. Midazolam and valproate were administered up to the maximum therapeutic dose, and FBDS continued to recur once every 1-2 h. After adding topiramate, the seizures resolved. A psychoorganic syndrome developed, with a predominance of an excitatory component, deterioration of cognitive functions, especially memory, heteroaggression, automatization, hyperphagia, use of vulgarisms, and sleep biorhythm was disturbed. EEG showed encephalopathic recordings. MRI of the brain was negative. Psychological examination confirmed cognitive deterioration by approximately 1.5 years compared to calendar age. Basic oncological screening excluded paraneoplastic process. Re-examination of the lysate showed positivity of anti-LGI1 antibodies.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30103 - Neurosciences (including psychophysiology)
Result continuities
Project
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Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
CESKA A SLOVENSKA NEUROLOGIE A NEUROCHIRURGIE
ISSN
1210-7859
e-ISSN
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Volume of the periodical
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Issue of the periodical within the volume
3
Country of publishing house
CZ - CZECH REPUBLIC
Number of pages
3
Pages from-to
208-210
UT code for WoS article
001044269700001
EID of the result in the Scopus database
2-s2.0-85166397813