Pseudonormokalemia case report - What does it mean to have normal blood potassium?

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61988987%3A17110%2F24%3AA25038Z5" target="_blank" >RIV/61988987:17110/24:A25038Z5 - isvavai.cz</a>

Result on the web

<a href="https://www.biochemia-medica.com/en/journal/34/2/10.11613/BM.2024.021002" target="_blank" >https://www.biochemia-medica.com/en/journal/34/2/10.11613/BM.2024.021002</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.11613/bm.2024.021002" target="_blank" >10.11613/bm.2024.021002</a>

Result language

angličtina

Original language name

Pseudonormokalemia case report - What does it mean to have normal blood potassium?

Original language description

Graphical abstractHighlights• Pseudonormokalemia may mean thrombocytosis, serum potassium concentration within reference ranges, and low plasma potassium concentration• The best way to eliminate both pseudohyperkalemia and pseudonormokalemia phenomenon is to completely change towards heparin-plasma as the standard material• Interpretative comments in patients with thrombocytosis over 500x109/L recommending plasma potassium measurement are helpfulThis case report describes a case of pseudonormokalemia, true hypokalemia. Often, only laboratory values outside the normal range gain attention and false normal results are at risk of not being noticed. However, a disease state may be masked by another pathological process. Here, a 50-year old male was admitted to the Department of Internal Medicine due to sepsis from a dental infection. Initially, serum potassium measurement revealed a normal value of 4 mmol/L (reference interval 3.8-5.1 mmol/L). Thrombocyte number was above 500x109/L. Due to our policy to recommend a repeated measurement of potassium in whole blood or heparin plasma if a patient has thrombocytosis, pseudonormokalemia was identified because the heparin plasma potassium value was only 2.9 mmol/L (reference interval 3.5-4.8 mmol/L). The physiological difference between serum and plasma concentration is no more than 0.3 mmol/L. In this case, potassium concentration were falsely elevated in the serum sample, probably caused by the high number of platelets releasing potassium during clotting. Interpretative comments in patients with thrombocytosis over 500x109/L recommending plasma potassium measurement are helpful. The best way to eliminate pseudohyperkalemia and pseudonormokalemia phenomena caused by thrombocytosis is to completely change towards heparin plasma as the standard material.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

20602 - Medical laboratory technology (including laboratory samples analysis; diagnostic technologies) (Biomaterials to be 2.9 [physical characteristics of living material as related to medical implants, devices, sensors])

Project

—

Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2024

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

BIOCHEMIA MEDICA

ISSN

1330-0962

e-ISSN

1846-7482

Volume of the periodical

—

Issue of the periodical within the volume

2

Country of publishing house

HR - CROATIA

Number of pages

4

Pages from-to

362-365

UT code for WoS article

001254069100013

EID of the result in the Scopus database

2-s2.0-85196451648