Carotid plaque characteristics by computed Tomography: A diagnostic accuracy systematic review
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61988987%3A17110%2F25%3AA2603AU1" target="_blank" >RIV/61988987:17110/25:A2603AU1 - isvavai.cz</a>
Result on the web
<a href="https://linkinghub.elsevier.com/retrieve/pii/S2352906725000594" target="_blank" >https://linkinghub.elsevier.com/retrieve/pii/S2352906725000594</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.ijcha.2025.101656" target="_blank" >10.1016/j.ijcha.2025.101656</a>
Alternative languages
Result language
angličtina
Original language name
Carotid plaque characteristics by computed Tomography: A diagnostic accuracy systematic review
Original language description
Beyond the stenosis degree, the carotid plaque morphology assessed by computed tomography may improve the stroke risk stratification and is recommended to be considered before interventional treatment according to current guidelines. This study aimed to systematically review the accuracy of computed tomography (CT) to detect carotid plaque characteristics compared to histology in patients with symptomatic and asymptomatic carotid plaques. We registered the protocol in PROSPERO and searched Medline Ovid, Embase.com, Cochrane Library, and Web of Science for diagnostic accuracy of CT in specific carotid plaque characteristic imaging compared to histology, without any search limitation up to May 27, 2022. Out of 8,168 studies, 20 studies that evaluated seven specific plaque characteristics were included in our systematic review. The best diagnostic performance was found for the detection of ulceration (sensitivity range 39.4–100% [mean 79.6%], specificity range 74–100% [mean 93.6%]), followed by calcification (72.7–100% [88.1%], 35.7–100% [80.1%]), lipid-rich necrotic core (63.2–95.6% [81.1%], 60–100% [80.1%]), and intraplaque hemorrhage (61.5–100% [86%], 20–99.5% [67.8%]). Only a few studies evaluated specifically vulnerable, mixed, and fibrous plaque. Diagnostic studies with larger sample sizes are needed, using novel available CT techniques that enable increasing diagnostic performance and decreasing radiation and amount of contrast agent. CT allows for highly accurate detection of carotid plaque features, particularly ulceration and calcification. These results underline the role of routine CT examinations to assess not only stenosis degree but also plaque morphology and individual patient stroke risk to better guide management. Registration: PROSPERO ID CRD42022329690 (https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=329690)
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30224 - Radiology, nuclear medicine and medical imaging
Result continuities
Project
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Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
IJC Heart & Vasculature
ISSN
2352-9067
e-ISSN
2352-9067
Volume of the periodical
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Issue of the periodical within the volume
June 2025
Country of publishing house
IE - IRELAND
Number of pages
10
Pages from-to
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UT code for WoS article
001453443200001
EID of the result in the Scopus database
2-s2.0-105000238644