Sculpting the endomembrane system in deep time: high resolution phylogenetics of Rab GTPases

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61988987%3A17310%2F12%3AA130176D" target="_blank" >RIV/61988987:17310/12:A130176D - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Sculpting the endomembrane system in deep time: high resolution phylogenetics of Rab GTPases
Original language description
We have devised and exploited a new phylogenetic strategy to reconstruct the history of the Rab GTPases, a key family of endomembrane-specificity proteins. Strikingly, we infer a remarkably sophisticated organellar composition for the last eukaryotic common ancestor, which we predict possessed as many as 23 Rab GTPases. This repertoire is significantly greater than that present in many modern organisms and indicates a major role for secondary loss in the evolutionary diversification of the endomembranesystem. Furthermore, we show that many Rab paralogues emerged relatively suddenly during early metazoan evolution, which is in stark contrast to the lack of significant Rab family expansions at the onset of most other major eukaryotic groups. Finally, wereconstruct higher-order ancestral clades of Rabs primarily linked with endocytic and exocytic process, suggesting the presence of primordial Rabs associated with the establishment of those pathways.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Project
<a href="/en/project/GAP305%2F10%2F0205" target="_blank" >GAP305/10/0205: The Ras superfamily of GTPases and the evolution of the eukaryotic cell</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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