Bioinformatics analyses and in vitro evidence for five and six stacked G-quadruplex forming sequences

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61988987%3A17310%2F18%3AA1901UJS" target="_blank" >RIV/61988987:17310/18:A1901UJS - isvavai.cz</a>

Alternative codes found

RIV/68081707:_____/18:00491059 RIV/86652079:_____/18:00491059

Result on the web

<a href="http://dx.doi.org/10.1016/j.biochi.2018.05.002" target="_blank" >http://dx.doi.org/10.1016/j.biochi.2018.05.002</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.biochi.2018.05.002" target="_blank" >10.1016/j.biochi.2018.05.002</a>

Result language

angličtina

Original language name

Bioinformatics analyses and in vitro evidence for five and six stacked G-quadruplex forming sequences

Original language description

Quadruplexes are noncanonical DNA structures that arise in guanine rich loci and have important bio-logical functions. Classically, quadruplexes contain four stacked intramolecular G-tetrads. Surprisingly,although some algorithms allow searching for longer than 4G tracts for quadruplex formation, these havenot yet been systematically studied. Therefore, we analyzed the human genome for sequences that arepredicted to adopt stacked intramolecular G-tetrads with greater than four stacks. The data provideevidence for numerous G-quadruplexes that contain five or six stacked intramolecular G-tetrads. Thesesequences are predominantly found in known gene regulatory regions. Electrophoretic mobility assaysand circular dichroism spectroscopy indicate that these sequences form quadruplex structures in vitrounder physiological conditions. The localization and in vitro stability of these G-quadruplexes indicatetheir potentially important roles in gene regulation and their potential for therapeutic applications.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10608 - Biochemistry and molecular biology

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

BIOCHIMIE

ISSN

0300-9084

e-ISSN

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Volume of the periodical

150

Issue of the periodical within the volume

July

Country of publishing house

FR - FRANCE

Number of pages

6

Pages from-to

70-75

UT code for WoS article

000434053900009

EID of the result in the Scopus database

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