DNA polymerase eta mutational signatures are found in a variety of different types of cancer.
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61988987%3A17310%2F18%3AA1901X0W" target="_blank" >RIV/61988987:17310/18:A1901X0W - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1080/15384101.2017.1404208" target="_blank" >http://dx.doi.org/10.1080/15384101.2017.1404208</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1080/15384101.2017.1404208" target="_blank" >10.1080/15384101.2017.1404208</a>
Alternative languages
Result language
angličtina
Original language name
DNA polymerase eta mutational signatures are found in a variety of different types of cancer.
Original language description
DNA polymerase (pol) is a specialized error-prone polymerase with at least two quite different and contrasting cellular roles: to mitigate the genetic consequences of solar UV irradiation, and promote somatic hypermutation in the variable regions of immunoglobulin genes. Misregulation and mistargeting of pol can compromise genome integrity. We explored whether the mutational signature of pol could be found in datasets of human somatic mutations derived from normal and cancer cells. A substantial excess of single and tandem somatic mutations within known pol mutable motifs was noted in skin cancer as well as in many other types of human cancer, suggesting that somatic mutations in A:T bases generated by DNA polymerase are a common feature of tumorigenesis. Another peculiarity of pol mutational signatures, mutations in YCG motifs, led us to speculate that error-prone DNA synthesis opposite methylated CpG dinucleotides by misregulated pol in tumors might constitute an additional mechanism of cytosine demethylation in this hypermutable dinucleotide.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10601 - Cell biology
Result continuities
Project
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Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
CELL CYCLE
ISSN
1538-4101
e-ISSN
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Volume of the periodical
17
Issue of the periodical within the volume
3
Country of publishing house
US - UNITED STATES
Number of pages
8
Pages from-to
348-355
UT code for WoS article
000430207100014
EID of the result in the Scopus database
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