Diverse roles of RAD18 and Y-family DNA polymerases in tumorigenesis
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61988987%3A17310%2F18%3AA1901X15" target="_blank" >RIV/61988987:17310/18:A1901X15 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1080/15384101.2018.1456296" target="_blank" >http://dx.doi.org/10.1080/15384101.2018.1456296</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1080/15384101.2018.1456296" target="_blank" >10.1080/15384101.2018.1456296</a>
Alternative languages
Result language
angličtina
Original language name
Diverse roles of RAD18 and Y-family DNA polymerases in tumorigenesis
Original language description
Mutagenesis is a hallmark and enabling characteristic of cancer cells. The E3 ubiquitin ligase RAD18 and its downstream effectors, the Y-family' Trans-Lesion Synthesis (TLS) DNA polymerases, confer DNA damage tolerance at the expense of DNA replication fidelity. Thus, RAD18 and TLS polymerases are attractive candidate mediators of mutagenesis and carcinogenesis. The skin cancer-propensity disorder xeroderma pigmentosum-variant (XPV) is caused by defects in the Y-family DNA polymerase Pol eta (Pol). However it is unknown whether TLS dysfunction contributes more generally to other human cancers. Recent analyses of cancer genomes suggest that TLS polymerases generate many of the mutational signatures present in diverse cancers. Moreover biochemical studies suggest that the TLS pathway is often reprogrammed in cancer cells and that TLS facilitates tolerance of oncogene-induced DNA damage. Here we review recent evidence supporting widespread participation of RAD18 and the Y-family DNA polymerases in the different phases of multi-step carcinogenesis.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10601 - Cell biology
Result continuities
Project
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Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
CELL CYCLE
ISSN
1538-4101
e-ISSN
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Volume of the periodical
17
Issue of the periodical within the volume
7
Country of publishing house
US - UNITED STATES
Number of pages
11
Pages from-to
833-843
UT code for WoS article
000438399100004
EID of the result in the Scopus database
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