The oxymonad genome displays canonical eukaryotic complexity in the absence of a mitochondrion

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61988987%3A17310%2F19%3AA200229A" target="_blank" >RIV/61988987:17310/19:A200229A - isvavai.cz</a>

Alternative codes found

RIV/00216208:11310/19:10403765

Result on the web

<a href="https://watermark.silverchair.com/msz147.pdf?token=AQECAHi208BE49Ooan9kkhW_Ercy7Dm3ZL_9Cf3qfKAc485ysgAAAmQwggJgBgkqhkiG9w0BBwagggJRMIICTQIBADCCAkYGCSqGSIb3DQEHATAeBglghkgBZQMEAS4wEQQMR8Kao1iEMxi9XnL7AgEQgIICFw0o9oem1kuwCLKSddPOggCTZXqiibYkocj3PJbSJk9q_zV" target="_blank" >https://watermark.silverchair.com/msz147.pdf?token=AQECAHi208BE49Ooan9kkhW_Ercy7Dm3ZL_9Cf3qfKAc485ysgAAAmQwggJgBgkqhkiG9w0BBwagggJRMIICTQIBADCCAkYGCSqGSIb3DQEHATAeBglghkgBZQMEAS4wEQQMR8Kao1iEMxi9XnL7AgEQgIICFw0o9oem1kuwCLKSddPOggCTZXqiibYkocj3PJbSJk9q_zV</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1093/molbev/msz147" target="_blank" >10.1093/molbev/msz147</a>

Result language

angličtina

Original language name

The oxymonad genome displays canonical eukaryotic complexity in the absence of a mitochondrion

Original language description

The discovery that the protist Monocercomonoides exilis completely lacks mitochondria demonstrates that these organelles are not absolutely essential to eukaryotic cells. However, the degree to which the metabolism and cellular systems of this organism have adapted to the loss of mitochondria is unknown. Here, we report an extensive analysis of the M. exilis genome to address this question. Unexpectedly, we find that M. exilis genome structure and content is similar in complexity to other eukaryotes and less 'reduced' than genomes of some other protists from the Metamonada group to which it belongs. Furthermore, the predicted cytoskeletal systems, the organization of endomembrane systems, and biosynthetic pathways also display canonical eukaryotic complexity. The only apparent preadaptation that permitted the loss of mitochondria was the acquisition of the SUF system for Fe-S cluster assembly and the loss of glycine cleavage system. Changes in other systems, including in amino acid metabolism and oxidative stress response, were coincident with the loss of mitochondria but are likely adaptations to the microaerophilic and endobiotic niche rather than the mitochondrial loss per se. Apart from the lack of mitochondria and peroxisomes, we show that M. exilis is a fully elaborated eukaryotic cell that is a promising model system in which eukaryotic cell biology can be investigated in the absence of mitochondria.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10603 - Genetics and heredity (medical genetics to be 3)

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2019

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Molecular Biology and Evolution

ISSN

0737-4038

e-ISSN

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Volume of the periodical

36

Issue of the periodical within the volume

10

Country of publishing house

GB - UNITED KINGDOM

Number of pages

21

Pages from-to

2292-2312

UT code for WoS article

000501734200017

EID of the result in the Scopus database

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