Visceral fat and insulin resistance - what we know?
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61988987%3A17310%2F19%3AA22025GP" target="_blank" >RIV/61988987:17310/19:A22025GP - isvavai.cz</a>
Result on the web
<a href="https://biomed.papers.upol.cz/artkey/bio-201901-0003_visceral_fat_and_insulin_resistance_-_what_we_know.php?back=%2Fsearch.php%3Fquery%3DVisceral%2Bfat%2Band%2Binsulin%2Bresistance%2B-%2Bwhat%2Bwe%2Bknow%253F%2Bin%253Aauth%2Bname%2Bkey%2Babstr%26sfrom%3D" target="_blank" >https://biomed.papers.upol.cz/artkey/bio-201901-0003_visceral_fat_and_insulin_resistance_-_what_we_know.php?back=%2Fsearch.php%3Fquery%3DVisceral%2Bfat%2Band%2Binsulin%2Bresistance%2B-%2Bwhat%2Bwe%2Bknow%253F%2Bin%253Aauth%2Bname%2Bkey%2Babstr%26sfrom%3D</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.5507/bp.2018.062" target="_blank" >10.5507/bp.2018.062</a>
Alternative languages
Result language
angličtina
Original language name
Visceral fat and insulin resistance - what we know?
Original language description
One of the most significant challenges of current medicine is the increasing prevalence of obesity worldwide that is accompanied by a wide range of chronic health complications and increased mortality. White adipose tissue actively contributes to metabolic regulation by production of a variety of hormones and cytokines, commonly referred to as adipokines. The spectrum and quantity of adipokines produced by the adipose tissue of obese patients is directly or indirectly involved in much obesity-related pathology (type 2 diabetes mellitus, cardiovascular disease, inflammatory response). One of the underlying mechanisms linking obesity, diabetes, and cardiovascular complications is subclinical inflammation, primarily arising in visceral adipose tissue. Adipocyte size, number and polarization of lymphocytes and infiltrated macrophages are closely related to metabolic and obesity-related diseases. The storage capacity of hypertrophic adipocytes in obese patients is limited. This results in chronic energy overload and leads to increased apoptosis of adipocytes that in turn stimulates the infiltration of visceral adipose tissue by immune cells, in particular macrophages. These cells produce many proinflammatory factors; while the overall production of anti-inflammatory cytokines and adipokines is decreased. The constant release of proinflammatory factors into the circulation then contributes to a subclinical systemic inflammation, which is directly linked to the metabolic and cardiovascular complications of obesity.
Czech name
—
Czech description
—
Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
30202 - Endocrinology and metabolism (including diabetes, hormones)
Result continuities
Project
—
Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Biomedical Papers
ISSN
1213-8118
e-ISSN
1804-7521
Volume of the periodical
163
Issue of the periodical within the volume
1
Country of publishing house
CZ - CZECH REPUBLIC
Number of pages
8
Pages from-to
19-27
UT code for WoS article
000458362500003
EID of the result in the Scopus database
—