Lymphocytes and macrophages in adipose tissue in obesity: markers or makers of subclinical inflammation?

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F17%3A00075919" target="_blank" >RIV/00023001:_____/17:00075919 - isvavai.cz</a>

Alternative codes found

RIV/00023761:_____/17:N0000009 RIV/00216208:11110/17:10360806 RIV/00064165:_____/17:10360806

Result on the web

<a href="https://link.springer.com/content/pdf/10.1007%2Fs00709-017-1082-3.pdf" target="_blank" >https://link.springer.com/content/pdf/10.1007%2Fs00709-017-1082-3.pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00709-017-1082-3" target="_blank" >10.1007/s00709-017-1082-3</a>

Result language

angličtina

Original language name

Lymphocytes and macrophages in adipose tissue in obesity: markers or makers of subclinical inflammation?

Original language description

Obesity is accompanied by the development of chronic low-grade inflammation in adipose tissue. The presence of chronic inflammatory response along with metabolically harmful factors released by adipose tissue into the circulation is associated with several metabolic complications of obesity such as type 2 diabetes mellitus or accelerated atherosclerosis. The present review is focused on macrophages and lymphocytes and their possible role in low-grade inflammation in fat. Both macrophages and lymphocytes respond to obesity-induced adipocyte hypertrophy by their migration into adipose tissue. After activation and differentiation, they contribute to the development of local inflammatory response and modulation of endocrine function of adipose tissue. Despite intensive research, the exact role of lymphocytes and macrophages within adipose tissue is only partially clarified and various data obtained by different approaches bring ambiguous information with respect to their polarization and cytokine production. Compared to immunocompetent cells, the role of adipocytes in the obesity-related adipose tissue inflammation is often underestimated despite their abundant production of factors with immunomodulatory actions such as cytokines or adipokines such as leptin, adiponektin, and others. In summary, conflicting evidence together with only partial correlation of in vitro findings with true in vivo situation due to great heterogeneity and molecular complexity of tissue environment calls for intensive research in this rapidly evolving and important area.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30202 - Endocrinology and metabolism (including diabetes, hormones)

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Protoplasma

ISSN

0033-183X

e-ISSN

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Volume of the periodical

254

Issue of the periodical within the volume

3

Country of publishing house

AT - AUSTRIA

Number of pages

14

Pages from-to

1219-1232

UT code for WoS article

000399037400009

EID of the result in the Scopus database

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