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Suicidal Leishmania

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61988987%3A17310%2F20%3AA21025CV" target="_blank" >RIV/61988987:17310/20:A21025CV - isvavai.cz</a>

  • Alternative codes found

    RIV/60077344:_____/20:00540011 RIV/60076658:12310/20:43901103 RIV/00216208:11310/20:10411490

  • Result on the web

    <a href="https://www.mdpi.com/2076-0817/9/2/79" target="_blank" >https://www.mdpi.com/2076-0817/9/2/79</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.3390/pathogens9020079" target="_blank" >10.3390/pathogens9020079</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Suicidal Leishmania

  • Original language description

    Leishmania are obligate intracellular parasites known to have developed successful ways of efficient immunity evasion. Because of this, leishmaniasis, a disease caused by these flagellated protists, is ranked as one of the most serious tropical infections worldwide. Neither prophylactic medication, nor vaccination has been developed thus far, even though the infection has usually led to strong and long-lasting immunity. In this paper, we describe a 'suicidal' system established in Leishmania mexicana, a human pathogen causing cutaneous leishmaniasis. This system is based on the expression and (de)stabilization of a basic phospholipase A2 toxin from the Bothrops pauloensis snake venom, which leads to the inducible cell death of the parasites in vitro. Furthermore, the suicidal strain was highly attenuated during macrophage infection, regardless of the toxin stabilization. Such a deliberately weakened parasite could be used to vaccinate the host, as its viability is regulated by the toxin stabilization, causing a profoundly reduced pathogenesis.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30109 - Pathology

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2020

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    PATHOGENS

  • ISSN

    2076-0817

  • e-ISSN

    2076-0817

  • Volume of the periodical

    9

  • Issue of the periodical within the volume

    2

  • Country of publishing house

    CH - SWITZERLAND

  • Number of pages

    12

  • Pages from-to

  • UT code for WoS article

    000519242900073

  • EID of the result in the Scopus database