Suicidal Leishmania
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61988987%3A17310%2F20%3AA21025CV" target="_blank" >RIV/61988987:17310/20:A21025CV - isvavai.cz</a>
Alternative codes found
RIV/60077344:_____/20:00540011 RIV/60076658:12310/20:43901103 RIV/00216208:11310/20:10411490
Result on the web
<a href="https://www.mdpi.com/2076-0817/9/2/79" target="_blank" >https://www.mdpi.com/2076-0817/9/2/79</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/pathogens9020079" target="_blank" >10.3390/pathogens9020079</a>
Alternative languages
Result language
angličtina
Original language name
Suicidal Leishmania
Original language description
Leishmania are obligate intracellular parasites known to have developed successful ways of efficient immunity evasion. Because of this, leishmaniasis, a disease caused by these flagellated protists, is ranked as one of the most serious tropical infections worldwide. Neither prophylactic medication, nor vaccination has been developed thus far, even though the infection has usually led to strong and long-lasting immunity. In this paper, we describe a 'suicidal' system established in Leishmania mexicana, a human pathogen causing cutaneous leishmaniasis. This system is based on the expression and (de)stabilization of a basic phospholipase A2 toxin from the Bothrops pauloensis snake venom, which leads to the inducible cell death of the parasites in vitro. Furthermore, the suicidal strain was highly attenuated during macrophage infection, regardless of the toxin stabilization. Such a deliberately weakened parasite could be used to vaccinate the host, as its viability is regulated by the toxin stabilization, causing a profoundly reduced pathogenesis.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30109 - Pathology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
PATHOGENS
ISSN
2076-0817
e-ISSN
2076-0817
Volume of the periodical
9
Issue of the periodical within the volume
2
Country of publishing house
CH - SWITZERLAND
Number of pages
12
Pages from-to
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UT code for WoS article
000519242900073
EID of the result in the Scopus database
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