Catalase impairs Leishmania mexicana development and virulence
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61988987%3A17310%2F21%3AA2202AEL" target="_blank" >RIV/61988987:17310/21:A2202AEL - isvavai.cz</a>
Alternative codes found
RIV/61988987:17310/21:A2202BOX RIV/00216208:11310/21:10426278
Result on the web
<a href="https://www.tandfonline.com/doi/full/10.1080/21505594.2021.1896830" target="_blank" >https://www.tandfonline.com/doi/full/10.1080/21505594.2021.1896830</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1080/21505594.2021.1896830" target="_blank" >10.1080/21505594.2021.1896830</a>
Alternative languages
Result language
angličtina
Original language name
Catalase impairs Leishmania mexicana development and virulence
Original language description
Catalase is one of the most abundant enzymes on Earth. It decomposes hydrogen peroxide, thus protecting cells from dangerous reactive oxygen species. The catalase-encoding gene is conspicuously absent from the genome of most representatives of the family Trypanosomatidae. Here, we expressed this protein from the Leishmania mexicana Beta-TUBULIN locus using a novel bicistronic expression system, which relies on the 2A peptide of Teschovirus A. We demonstrated that catalase-expressing parasites are severely compromised in their ability to develop in insects, to be transmitted and to infect mice, and to cause clinical manifestation in their mammalian host. Taken together, our data support the hypothesis that the presence of catalase is not compatible with the dixenous life cycle of Leishmania, resulting in loss of this gene from the genome during the evolution of these parasites.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10606 - Microbiology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Virulence
ISSN
2150-5594
e-ISSN
2150-5608
Volume of the periodical
12
Issue of the periodical within the volume
1
Country of publishing house
US - UNITED STATES
Number of pages
17
Pages from-to
852-867
UT code for WoS article
000629356700001
EID of the result in the Scopus database
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