Synthesis and Disinfection Effect of the Pyridine-4-aldoxime Based Salts

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989100%3A27240%2F15%3A86091653" target="_blank" >RIV/61989100:27240/15:86091653 - isvavai.cz</a>

Alternative codes found

RIV/60162694:G44__/15:43875385 RIV/00216208:11160/15:10294116 RIV/00179906:_____/15:10294116

Result on the web

<a href="http://dx.doi.org/10.3390/molecules20033681" target="_blank" >http://dx.doi.org/10.3390/molecules20033681</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/molecules20033681" target="_blank" >10.3390/molecules20033681</a>

Result language

angličtina

Original language name

Synthesis and Disinfection Effect of the Pyridine-4-aldoxime Based Salts

Original language description

A set of new quaternary ammonium compounds based on pyridine-4-aldoxime was synthesized, characterized with analytical data (NMR, EA, HPLC, MS) and tested for in vitro antimicrobial activity (antibacterial, antifungal) and cytotoxicity. Quaternary pyridinium-4-aldoxime salts with length of alkyl side chain from C8 to C20 and belonging to the group of cationic surfactants were investigated in this work. An HPLC experimental protocol for characterization of mixtures of all homologues has been found. Antimicrobial evaluation found that yeast-type fungi were most sensitive towards C14 and C16 analogues, whereas the C16 analogue was completely ineffective against filamentous fungi. Antibacterial assessment showed versatility of C14 and relatively high efficacy of C16 against G+ strains and C14 against GMINUS SIGN strains. Notably, none of the studied compounds exceeded the efficacy and versatility of the benzalkonium C12 analogue, and benzalkonium analogues also exhibited lower cytotoxicity

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EE - Microbiology, virology

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Molecules

ISSN

1420-3049

e-ISSN

—

Volume of the periodical

20

Issue of the periodical within the volume

3

Country of publishing house

CH - SWITZERLAND

Number of pages

16

Pages from-to

3681-3696

UT code for WoS article

000352471300010

EID of the result in the Scopus database

2-s2.0-84929170738