Synthesis, Antimicrobial Effect and Lipophilicity-Activity Dependence of Three Series of Dichained N-Alkylammonium Salts
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F19%3A00537389" target="_blank" >RIV/60162694:G44__/19:00537389 - isvavai.cz</a>
Alternative codes found
RIV/00179906:_____/19:10402699
Result on the web
<a href="https://onlinelibrary.wiley.com/doi/10.1002/slct.201902357" target="_blank" >https://onlinelibrary.wiley.com/doi/10.1002/slct.201902357</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/slct.201902357" target="_blank" >10.1002/slct.201902357</a>
Alternative languages
Result language
angličtina
Original language name
Synthesis, Antimicrobial Effect and Lipophilicity-Activity Dependence of Three Series of Dichained N-Alkylammonium Salts
Original language description
Quaternary ammonium salts belong to the group of cationic surfactants and their structure, especially the length of the alkyl chain, plays a significant role in its activity against various microorganisms. Globally, there is a growing need to develop novel compounds due to the increasing resistance of microorganisms to antimicrobial agents. Three series of quaternary ammonium compounds based on dichained N-alkylammonium salts were synthesized with different carbon chain lengths (C-8, C-10, C-12, C-14, C-16). These compounds were characterized with analytical methods and tested in vitro for antibacterial, antifungal, antiviral and antialgal activities. In addition, the determination of their critical micelle concentrations, lipophilicity and cytotoxicity were likewise performed to assess potential lipophilicity-activity dependence. Almost all compounds showed a high efficacy against bacterial and fungal strains. Significant effects against Varicella zoster virus and algae were also noticed. Some of novel drugs outperformed standard benzalkonium salts. The expected trend of the correlation of an increase of cytotoxicity with the length of carbon chain was confirmed. These compounds show a higher potential as disinfectants rather than antiseptics due to their cytotoxic potential and low selectivity for microbes over mammalian cells.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10400 - Chemical sciences
Result continuities
Project
<a href="/en/project/NV18-09-00181" target="_blank" >NV18-09-00181: Development of polyvalent decontamination mean</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
ChemistrySelect
ISSN
2365-6549
e-ISSN
2365-6549
Volume of the periodical
4
Issue of the periodical within the volume
41
Country of publishing house
DE - GERMANY
Number of pages
9
Pages from-to
12076-12084
UT code for WoS article
000495129900016
EID of the result in the Scopus database
2-s2.0-85075008649