Neutrophils in chronic lymphocytic leukemia are permanently activated and have functional defects

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989100%3A27240%2F17%3A10238713" target="_blank" >RIV/61989100:27240/17:10238713 - isvavai.cz</a>
Alternative codes found
RIV/61989592:15110/17:73582608
Result on the web
<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5689581/" target="_blank" >https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5689581/</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.18632/oncotarget.20031" target="_blank" >10.18632/oncotarget.20031</a>

Result language
angličtina
Original language name
Neutrophils in chronic lymphocytic leukemia are permanently activated and have functional defects
Original language description
A growing body of studies highlights involvement of neutrophils in cancer development and progression. Our aim was to assess the phenotypic and functional properties of circulating neutrophils from patients with chronic lymphocytic leukemia (CLL). The percentage of CD54+ and CD64+ neutrophils as well as CD54 expression on these cells were higher in CLL patients than in age-matched healthy controls. Neutrophils from CLL produced more reactive oxygen species (ROS) compared to controls in both resting and activated conditions. Lipopolysaccharide-induced production of IL-1β and TNF-α as well as reduced TLR2 expression in neutrophils from CLL than in neutrophils from controls suggesting their tolerant state. Finally, phenotypic alterations of neutrophils, particularly elevation of CD64 and CD54 markers, correlated with disease activity and treatment, and low percentage of neutrophils. Taken together, the alterations in percentage and functional characteristics of neutrophils reflect the clinical course of CLL. Our data provide first evidence that neutrophils in CLL are permanently primed and have functional defects. © Manukyan et al.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10201 - Computer sciences, information science, bioinformathics (hardware development to be 2.2, social aspect to be 5.8)

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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