Hard gelatine capsules: DEM supported experimental study of particle arrangement effect on properties and vibrational transport behaviour
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989100%3A27350%2F22%3A10250247" target="_blank" >RIV/61989100:27350/22:10250247 - isvavai.cz</a>
Alternative codes found
RIV/61989100:27730/22:10250247
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S0032591022004193" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0032591022004193</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.powtec.2022.117525" target="_blank" >10.1016/j.powtec.2022.117525</a>
Alternative languages
Result language
angličtina
Original language name
Hard gelatine capsules: DEM supported experimental study of particle arrangement effect on properties and vibrational transport behaviour
Original language description
Hard gelatine capsules remain a relevant dosage form for today's pharmaceutical manufacturing. A wide range of colour and print options supports marketing, brand image and patient loyalty. However, the filling of these capsules with various modern dosage forms and combinations thereof may affect their further processing. Therefore, a detailed study was carried out to assess the effect of mechanical-physical properties on the behaviour of differently filled hard gelatine capsules. Capsules filled with powder, free or fixed particles presenting drug microforms and also hard gelatine capsules themselves were evaluated. Basic mechanical-physical characterisation was performed on all samples. Furthermore, their transport on the vibrating conveyor was assessed and simulated using DEM. The results showed a significant influence mainly by the degree of capsule imbalance, i.e., the arrangement of particles in the capsule. It was found that the hard gelatine capsules showed an average of 15.6o lower values for the effective angle of internal friction compared to the powdered vitamin mixture, and in parallel, an average of 14.7o lower values for the static angle of repose were also recorded. The results of the experiments on the vibrating conveyor at a frequency setting of 15 Hz showed three times longer transport time for the vitamin mixture compared to the capsules. Increasing the frequency evened out these differences. (C) 2022 Elsevier B.V.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
20402 - Chemical process engineering
Result continuities
Project
<a href="/en/project/EF19_073%2F0016945" target="_blank" >EF19_073/0016945: Doctoral grant competition VŠB - TU Ostrava</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Powder technology
ISSN
0032-5910
e-ISSN
1873-328X
Volume of the periodical
405
Issue of the periodical within the volume
117525
Country of publishing house
US - UNITED STATES
Number of pages
19
Pages from-to
nestrankovano
UT code for WoS article
000809689300003
EID of the result in the Scopus database
2-s2.0-85130794088