Polymeric Nanocomposite with Antibacterial and Antitumoral Particles

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989100%3A27360%2F16%3A86099188" target="_blank" >RIV/61989100:27360/16:86099188 - isvavai.cz</a>
Alternative codes found
RIV/61989100:27640/16:86099188 RIV/61989100:27740/16:86099188
Result on the web
<a href="http://dx.doi.org/10.1166/asl.2016.6990" target="_blank" >http://dx.doi.org/10.1166/asl.2016.6990</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1166/asl.2016.6990" target="_blank" >10.1166/asl.2016.6990</a>

Result language
angličtina
Original language name
Polymeric Nanocomposite with Antibacterial and Antitumoral Particles
Original language description
The aim of this research work was to find out the suitability of selected polymeric matrices for the further studies of nanocomposites with antibacterial and antitumoral properties to use it in medicine. The selected for the study biodegradable triblock copolymers are polycaprolactone polyethylene glycol polycaprolactone (PCL-PEG-PCL) and polycaprolactone polyglycolic acid polycaprolactone (PCL-PGA-PCL) and as an antitumoral drug, Erlotinib was chosen. By means of molecular modeling, it was found that for both matrices, the bigger amount of drug is a reason of growing of cohesive energy density (CED). It means that the system is more stable having greater amount of drug. The case of polyethylene glycol (PEG) and polyglycolic acid (PGA) the data showed lower values of CED for PCL-PEG-PCL matrix the findings may indicate stronger interaction between Erlotinib and PGA than with PEG. This work is a first step for understanding the advantages and disadvantages of various materials for medical using.
Czech name
—
Czech description
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Project
<a href="/en/project/ED1.1.00%2F02.0070" target="_blank" >ED1.1.00/02.0070: IT4Innovations Centre of Excellence</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection
Advanced Science Letters : 4th Biennial Nanomaterials and Nanotechnology International Conference : proceedings : May 18-21, 2015, Ostrava, Czech Republic
ISBN
—
ISSN
1936-6612
e-ISSN
—
Number of pages
3
Pages from-to
685-687
Publisher name
American Scientific Publishers
Place of publication
Valencia
Event location
Ostrava
Event date
May 18, 2015
Type of event by nationality
WRD - Celosvětová akce
UT code for WoS article
000381233100019

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