Stability of Collagen Scaffold Implants for Animals with Iatrogenic Articular Cartilage Defects.

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16170%2F09%3A00002465" target="_blank" >RIV/62157124:16170/09:00002465 - isvavai.cz</a>

Alternative codes found

RIV/62157124:16170/09:00002447

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Stability of Collagen Scaffold Implants for Animals with Iatrogenic Articular Cartilage Defects.

Original language description

Synthesis and characterization of biodegradable hydrogels based on collagen modified by addition of synthetic biodegradable copolymer intended for preparation of porous scaffolds for mesenchymal stem cells used for possible implantation to animals with articular surface defects was investigated.The synthetic biodegradable tri-block copolymer used was the block copolymer of polyethylene glycol (PEG), polylactic acid (PLA), polyglycolic acid (PGA) (PEG-PLGA) endcapped with itaconic acid (ITA). The water-soluble carbodiimide and N-hydroxysuccimide system (EDC-NHS) was chosen as the cross-linking agent used to control the rate of hydrogel resorption. Dependence of the physical properties of the prepared hydrogels on the concentration of the EDC-NHS cross-linker, reaction time and concentration of PEG-PLGA-ITA copolymer was examined. Swelling behaviour, thermal stability, surface morphology and degradation rate were also characterized. Based on the obtained results, it can be concluded that

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FP - Other medical fields

OECD FORD branch

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Project

<a href="/en/project/2B06130" target="_blank" >2B06130: Synthesis of new biomaterials and preparation of stem cell derived cells, and their aplications in for the treatment of diseases affecting human tissues derived from mesoderm: cartilage, bone, ligament and meniscus.</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2009

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Acta veterinaria Brno

ISSN

0001-7213

e-ISSN

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Volume of the periodical

78

Issue of the periodical within the volume

4

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

6

Pages from-to

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UT code for WoS article

000273634200012

EID of the result in the Scopus database

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