Supercritical Fluid Extraction as a Method for Preparation of Submicron Particles of Cimetidine and Hydrochlorothiazide
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989100%3A27640%2F16%3A86099756" target="_blank" >RIV/61989100:27640/16:86099756 - isvavai.cz</a>
Alternative codes found
RIV/61989100:27740/16:86099756
Result on the web
<a href="http://dx.doi.org/10.1166/asl.2016.6988" target="_blank" >http://dx.doi.org/10.1166/asl.2016.6988</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1166/asl.2016.6988" target="_blank" >10.1166/asl.2016.6988</a>
Alternative languages
Result language
angličtina
Original language name
Supercritical Fluid Extraction as a Method for Preparation of Submicron Particles of Cimetidine and Hydrochlorothiazide
Original language description
This work is focused on preparation of submicron particles and nanoparticles of biologically active compounds using commercially supplied device designed for supercritical fluid extraction Spe-ed SFE-4. Working procedures were applied for the use of supercritical CO, as an anti-solvent for the micronization process of two commercially available drugs cimetidine and hydrochlorothiazide. Specifically, method called GAS (Gas Anti-solvent) was used at various temperatures, pressures and values of static phase length. The resulting products were characterized by scanning electron microscopy and particle size distribution. The aim of this work was to reduce particle sizes of given substances in order to increase their solubility in human body.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Advanced Science Letters : 4th Biennial Nanomaterials and Nanotechnology International Conference : proceedings : May 18-21, 2015, Ostrava, Czech Republic
ISSN
1936-6612
e-ISSN
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Volume of the periodical
22
Issue of the periodical within the volume
3
Country of publishing house
US - UNITED STATES
Number of pages
5
Pages from-to
670-674
UT code for WoS article
000381233100015
EID of the result in the Scopus database
2-s2.0-84985906257