Micronization of Ibuprofen Particles using Supercritical Fluid Technology
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989100%3A27640%2F19%3A10236623" target="_blank" >RIV/61989100:27640/19:10236623 - isvavai.cz</a>
Alternative codes found
RIV/61989100:27730/19:10236623 RIV/61989100:27740/19:10236623
Result on the web
<a href="https://www.ingentaconnect.com/content/asp/jnn/2019/00000019/00000005/art00047" target="_blank" >https://www.ingentaconnect.com/content/asp/jnn/2019/00000019/00000005/art00047</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1166/jnn.2019.15874" target="_blank" >10.1166/jnn.2019.15874</a>
Alternative languages
Result language
angličtina
Original language name
Micronization of Ibuprofen Particles using Supercritical Fluid Technology
Original language description
Most of drugs are only slightly soluble in the circulatory system of the human body. This reduces the efficiency of their use and that is why new ways how to increase their solubility are investigated. One way to improve the solubility of the drug is to reduce its particle size. Conventional techniques such as crushing or grinding usually do not guarantee a narrow particle size distribution, which is required for pharmaceuticals. Application of supercritical fluids, especially of supercritical CO2, seems to be convenient method for the preparation of pharmaceuticals submicron particles or nanoparticles. The method enables the preparation of particles in a narrow size distribution and at the same time it does not leave any unwanted residues of solvents or other chemicals. The aim of this work is the micronization of ibuprofen particles using the supercritical fluid and characterization of formed products. The micronization of the particles was done using commercially available device Spe-ed SFE-4 in rapid expansion of supercritical solution mode. The applied temperatures and pressures were 308.15 K and 313.15 K and 200, 250 and 300 bar. The prepared particles were characterized using methods of X-ray diffraction, infrared spectroscopy, particle size distribution, scanning electron microscopy and tests of dissolution and permeability. Mean particles size was reduced from 180 µm (original ibuprofen) to 2.8-7.3 µm of the processed samples. The dissolution test confirmed better solubility and the permeability of newly formed particles improved.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
21000 - Nano-technology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of nanoscience and nanotechnology
ISSN
1533-4880
e-ISSN
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Volume of the periodical
19
Issue of the periodical within the volume
5
Country of publishing house
US - UNITED STATES
Number of pages
7
Pages from-to
2814-2820
UT code for WoS article
000458402700047
EID of the result in the Scopus database
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