Metronidazole/clay nanocomposites: Synthesis, structure and antibacterial efficacy
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989100%3A27640%2F21%3A10246533" target="_blank" >RIV/61989100:27640/21:10246533 - isvavai.cz</a>
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S2214785320308476?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S2214785320308476?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.matpr.2020.02.101" target="_blank" >10.1016/j.matpr.2020.02.101</a>
Alternative languages
Result language
angličtina
Original language name
Metronidazole/clay nanocomposites: Synthesis, structure and antibacterial efficacy
Original language description
Clays are materials commonly used in the pharmaceutical industry, either as excipients or as active substances. It was observed that when they are administered concurrently, they may interact with drugs reducing their absorption. Such interactions can be used to achieve technological and biopharmaceutical advantages, regarding the control of release. Interactions between clay minerals and drugs may be biopharmaceutically beneficial to improve solubility and/or change drug release profile. This study is focused on the preparation and characterization of organoclay vermiculite and/or bentonite) nanocomposite materials based on imidazole derivative metronidazole, which is antibiotic drug used predominantly for treatment of intestinal and periodontal diseases. The structure of prepared samples was characterized by the X-ray diffractometry (XRD) and infrared spectroscopy (FTIR). Furthermore, the content of organic carbon was determined in the nanocomposite samples by multiphase carbon and hydrogen/ moisture analyzer. Antimicrobial activity of nanocomposites was tested against bacterial strains S. aureus, E. faecalis, P. aeruginosa and E. coli, and it was evaluated by finding minimum inhibitory concentration (MIC). It was found that antibacterial activity depends on pH and also on clay matrix.
Czech name
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Czech description
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Classification
Type
D - Article in proceedings
CEP classification
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OECD FORD branch
21001 - Nano-materials (production and properties)
Result continuities
Project
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Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Article name in the collection
Materials Today: Proceedings. Volume 37, Part 1
ISBN
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ISSN
2214-7853
e-ISSN
2214-7853
Number of pages
7
Pages from-to
21-27
Publisher name
Elsevier
Place of publication
Londýn
Event location
Ostrava
Event date
May 13, 2019
Type of event by nationality
WRD - Celosvětová akce
UT code for WoS article
000614126700004