Single Atom Engineered Antibiotics Overcome Bacterial Resistance
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989100%3A27640%2F24%3A10255951" target="_blank" >RIV/61989100:27640/24:10255951 - isvavai.cz</a>
Alternative codes found
RIV/61989592:15110/24:73625991 RIV/61989592:15310/24:73625991 RIV/61989592:15640/24:73625991 RIV/61989100:27740/24:10255951
Result on the web
<a href="https://onlinelibrary.wiley.com/doi/10.1002/adma.202410652" target="_blank" >https://onlinelibrary.wiley.com/doi/10.1002/adma.202410652</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/adma.202410652" target="_blank" >10.1002/adma.202410652</a>
Alternative languages
Result language
angličtina
Original language name
Single Atom Engineered Antibiotics Overcome Bacterial Resistance
Original language description
The outbreak of antibiotic-resistant bacteria, or "superbugs", poses a global public health hazard due to their resilience against the most effective last-line antibiotics. Identifying potent antibacterial agents capable of evading bacterial resistance mechanisms represents the ultimate defense strategy. This study shows that -the otherwise essential micronutrient- manganese turns into a broad-spectrum potent antibiotic when coordinated with a carboxylated nitrogen-doped graphene. This antibiotic material (termed NGA-Mn) not only inhibits the growth of a wide spectrum of multidrug-resistant bacteria but also heals wounds infected by bacteria in vivo and, most importantly, effectively evades bacterial resistance development. NGA-Mn exhibits up to 25-fold higher cytocompatibility to human cells than its minimum bacterial inhibitory concentration, demonstrating its potential as a next-generation antibacterial agent. Experimental findings suggest that NGA-Mn acts on the outer side of the bacterial cell membrane via a multimolecular collective binding, blocking vital functions in both Gram-positive and Gram-negative bacteria. The results underscore the potential of single-atom engineering toward potent antibiotics, offering simultaneously a long-sought solution for evading drug resistance development while being cytocompatible to human cells. (C) 2024 The Author(s). Advanced Materials published by Wiley-VCH GmbH.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10302 - Condensed matter physics (including formerly solid state physics, supercond.)
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Advanced Materials
ISSN
0935-9648
e-ISSN
1521-4095
Volume of the periodical
36
Issue of the periodical within the volume
50
Country of publishing house
DE - GERMANY
Number of pages
12
Pages from-to
2410652
UT code for WoS article
001317402300001
EID of the result in the Scopus database
2-s2.0-85204457710