T-2- and T-1 relaxivities and magnetic hyperthermia of iron-oxide nanoparticles combined with paramagnetic Gd complexes

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989100%3A27710%2F21%3A10247537" target="_blank" >RIV/61989100:27710/21:10247537 - isvavai.cz</a>
Result on the web
<a href="https://link.springer.com/article/10.1007/s12039-021-01904-7" target="_blank" >https://link.springer.com/article/10.1007/s12039-021-01904-7</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s12039-021-01904-7" target="_blank" >10.1007/s12039-021-01904-7</a>

Result language
angličtina
Original language name
T-2- and T-1 relaxivities and magnetic hyperthermia of iron-oxide nanoparticles combined with paramagnetic Gd complexes
Original language description
The present paper reports the synthesis of iron-oxide nanoparticles (diameter 12.8 +/- 2.2 nm) coated with silica shell doped with paramagnetic Gd(III)-based complexes. The resulting nanoparticles with a silica shell thickness of about 45 nm have an average diameter of 113.1 +/- 14.3 nm and feature high transverse and longitudinal relaxivities (356 and 25 mM(-1) s(-1), respectively) at 1.5 T and 25 degrees C on a medical whole body NMR scanner. It has been also revealed using magnetic heating measurements that the prepared core-shell nanoparticles possess a high specific adsorption rate of around 236 W/g in aqueous media. The surface of the composite nanoparticles was decorated by amino-groups for a greater cellular uptake behaviour. The cell viability measurements reveal the concentration-dependent cytotoxicity of the nanoparticles, which agrees well with the high content of Gd(III) complexes in the nanomaterial. The obtained results show that the core-shell design of nanoparticles with superparamagnetic and paramagnetic parts can be promising for high transverse (and longitudinal) relaxivity as well as magnetic hyperthermia.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
20400 - Chemical engineering

Project
<a href="/en/project/EF16_019%2F0000853" target="_blank" >EF16_019/0000853: Institute of Environmental Technology - Excellent Research</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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