Genetic and bioactive functionalization of bioinks for 3D bioprinting
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989100%3A27730%2F25%3A10257872" target="_blank" >RIV/61989100:27730/25:10257872 - isvavai.cz</a>
Result on the web
<a href="https://link.springer.com/article/10.1007/s00449-025-03180-y#citeas" target="_blank" >https://link.springer.com/article/10.1007/s00449-025-03180-y#citeas</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s00449-025-03180-y" target="_blank" >10.1007/s00449-025-03180-y</a>
Alternative languages
Result language
angličtina
Original language name
Genetic and bioactive functionalization of bioinks for 3D bioprinting
Original language description
3D bioprinting is revolutionizing tissue engineering and regenerative medicine by enabling the precise fabrication of biologically functional constructs. At its core, the success of 3D bioprinting hinges on the development of bioinks, hydrogel-based materials that support cellular viability, proliferation, and differentiation. However, conventional bioinks face limitations in mechanical strength, biological activity, and customization. Recent advancements in genetic engineering have addressed these challenges by enhancing the properties of bioinks through genetic modifications. These innovations allow the integration of stimuli-responsive elements, bioactive molecules, and extracellular matrix (ECM) components, significantly improving the mechanical integrity, biocompatibility, and functional adaptability of bioinks. This review explores the state-of-the-art genetic approaches to bioink development, emphasizing microbial engineering, genetic functionalization, and the encapsulation of growth factors. It highlights the transformative potential of genetically modified bioinks in various applications, including bone and cartilage regeneration, cardiac and liver tissue engineering, neural tissue reconstruction, and vascularization. While these advances hold promise for personalized and adaptive therapeutic solutions, challenges in scalability, reproducibility, and integration with multi-material systems persist. By bridging genetics and bioprinting, this interdisciplinary field paves the way for sophisticated constructs and innovative therapies in tissue engineering and regenerative medicine.
Czech name
—
Czech description
—
Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10400 - Chemical sciences
Result continuities
Project
—
Continuities
O - Projekt operacniho programu
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Bioprocess and Biosystems Engineering
ISSN
1615-7591
e-ISSN
1615-7605
Volume of the periodical
25
Issue of the periodical within the volume
20 05 2025
Country of publishing house
US - UNITED STATES
Number of pages
29
Pages from-to
nestránkováno
UT code for WoS article
001491332500001
EID of the result in the Scopus database
—