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THE IMPACT OF ORAL ESTRADIOL AND PROGESTERONE SUBSTITUTION ON ESTROGEN AND PROGESTERONE RECEPTORS EXPRESSION AND APOPTOSIS IN HUMAN ENDOMETRIUM

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F04%3A00000918" target="_blank" >RIV/61989592:15110/04:00000918 - isvavai.cz</a>

  • Alternative codes found

    RIV/61989592:15110/04:00002040

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    THE IMPACT OF ORAL ESTRADIOL AND PROGESTERONE SUBSTITUTION ON ESTROGEN AND PROGESTERONE RECEPTORS EXPRESSION AND APOPTOSIS IN HUMAN ENDOMETRIUM

  • Original language description

    Objective: Exogenous hormonal manipulation may alter physiological cyclic pattern of endometrium. This article evaluates the effect of oral estrogen-progesterone substitution on the expression of estrogen and progesterone receptors and the level of apoptosis in the secretory endometrium of substituted cycles by comparison with natural cycles in the same patient.Methods: Serum levels of estradiol (E2), SHBG and progesterone (P) were determined and bioptic samples of endometrium were taken on the 5th and7th day of luteal phase in 26 infertile women who entered the assisted reproduction program first in a spontaneous and later in an estrogen-progestagen substituted cycle. E and P receptors (ER and PR) were estimated by immunostaining and image analysis in stroma and glandular epithelium. The level of apoptosis was evaluated by the TUNEL assay. Wilcoxon matched-pairs test was used for the statistical analysis of data.Results: The mean serum levels of E2, SHBG and P were higher in substitu

  • Czech name

    Vliv estrogen-progestinové substituce na expresi estrogenových a progesteronových receptorů a apoptózu v lidském endometriu

  • Czech description

    Exogenní hormonální manipulace může mít vliv na změnu fyziologické cyklické struktury děložní sliznice. Tato studie hodnotí vliv orálně podávané náhrady estrogen-progesteronu na chování receptorů estrogenu a progesteronu a na hladinu apoptózy v sekrečnímendometriu nahrazených cyklů v porovnání s přirozenými cykly u stejného pacienta.

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    FK - Gynaecology and obstetrics

  • OECD FORD branch

Result continuities

  • Project

    <a href="/en/project/NH6611" target="_blank" >NH6611: Endometrial receptivity in relation to cryopreserved embryos transfer succes rate.</a><br>

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2004

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Acta Medica Martiniana

  • ISSN

    1335-8421

  • e-ISSN

  • Volume of the periodical

    4

  • Issue of the periodical within the volume

    2

  • Country of publishing house

    SK - SLOVAKIA

  • Number of pages

    7

  • Pages from-to

    22-28

  • UT code for WoS article

  • EID of the result in the Scopus database