Endometrial expression of the estrogen-sensitive genes MMP-26 and TIMP-4 is altered by a substitution protocol without down-regulation in IVF patiens
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F06%3A00003923" target="_blank" >RIV/61989592:15110/06:00003923 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Endometrial expression of the estrogen-sensitive genes MMP-26 and TIMP-4 is altered by a substitution protocol without down-regulation in IVF patiens
Original language description
BACKGROUND: The aim of this study was to analyse the effects of an estradiol (E2)?progesterone substitution protocol on the endometrial expression of estrogen-sensitive genes during the peri-implantation period. METHODS: Peripheral blood and endometrialbiopsies were obtained from 13 infertile women both in a natural cycle (NC), on days 5 and 7 after ovulation (NC5, NC7), and in an artificial (substituted) cycle (AC), on days 5 and 7 of progesterone addition (AC5, AC7). Estrogen receptor-? (ER ?) and progesterone receptor (PR) were assayed by immunohistochemistry. Matrix metalloproteinase-26 (MMP-26) mRNA and tissue inhibitor of metalloproteinase-4 (TIMP-4) mRNA were semiquantitatively assessed in tissue sections using in situ hybridization (ISH) and quantified in tissue extracts using real-time PCR. RESULTS: Levels of both E2 and progesterone were higher in the peripheral blood in AC than in NC. Also on day AC5, expressions of ER ?, PR and MMP-26 mRNA (focally) were increased in the e
Czech name
Endometrální exprese estrogen senzitivních genů MMP-26 a TIMP-4 je změněna substitučním protokolem bez downregulace u IVF pacientek
Czech description
Estradiol/progesteronová substituce vyvolává dramatické změny v expresi estrogen senzitivních genů MMP-26 a TIMP-4, které mohou nepříznivě ovlivnit výsledek IVF.
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FK - Gynaecology and obstetrics
OECD FORD branch
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Result continuities
Project
<a href="/en/project/NH6611" target="_blank" >NH6611: Endometrial receptivity in relation to cryopreserved embryos transfer succes rate.</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2006
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Human Reproduction Update
ISSN
1355-4786
e-ISSN
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Volume of the periodical
21
Issue of the periodical within the volume
12
Country of publishing house
GB - UNITED KINGDOM
Number of pages
11
Pages from-to
3146-3156
UT code for WoS article
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EID of the result in the Scopus database
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