Interaction of aromatic cytokinins with human liver microsomal cytochromes P450

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F05%3A00001931" target="_blank" >RIV/61989592:15110/05:00001931 - isvavai.cz</a>
Alternative codes found
RIV/61389030:_____/05:00083394
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Interaction of aromatic cytokinins with human liver microsomal cytochromes P450
Original language description
Aromatic cytokinins (ortho-topolin riboside, 6-benzylaminopurine riboside and 6-(2-hydroxy-3-methoxybenzylamino)purine riboside) were tested for their possible interaction with human liver microsomal cytochromes P450 by absorption difference spectroscopy. All three compounds were shown to bind to the CYP enzymes producing a high to low spin shift of the heme iron yielding a Soret absorption band shift to approximately 425 nm. As this type of spectral change means that the substance is able to bind directly to the heme iron, the results obtained open the possibility of an interaction of these compounds with metabolism of other drugs or, in general, with other substrates of cytochromes P450.
Czech name
Interakce aromatických cytokininů s lidskými mikrosomálními cytochromy P450
Czech description
Aromatické aminopuriny účinné jako cytokininy a inhibitory CDK, interagují s lidskými mikrosomálními jaterními cytochromy P450. Spektroskopické studium ukázalo, že afinita těchto látek koreluje s jejich polaritou.

Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CE - Biochemistry
OECD FORD branch
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Publication year
2005
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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