Investigation of sanguinarine and chelerythrine effects on CYP1A1 expression and activity in human hepatoma cells

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F06%3A00002715" target="_blank" >RIV/61989592:15110/06:00002715 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Investigation of sanguinarine and chelerythrine effects on CYP1A1 expression and activity in human hepatoma cells

Original language description

Quaternary benzo[c]phenanthridine alkaloids (QBA) sanguinarine and chelerythrine exhibit a wide spectrum of biological activities whence they are used in dental care products. Recent studies indicated that cytochrome P450 CYP1A attenuates sanguinarine toxicity both in vivo [Williams, M.K., Dalvi, S., Dalvi, R.R., 2000. Influence of 3-methylcholanthrene pretreatment on sanguinarine toxicity in mice. Vet. Hum. Toxicol. 42, 196-198] and in vitro [Vrba, J., Kosina, P., Ulrichová, J., Modrianský, M., 2004. Involvement of cytochrome P450 1A in sanguinarine detoxication. Toxicol. Lett. 151, 375-387]. However, CYP1A converts sanguinarine to the products that form DNA adducts [Stiborová, M., Šimánek, V., Frei, E., Hobza, P., Ulrichová, J., 2002. DNA adduct formation from quaternary benzo[c]phenanthridine alkaloids sanguinarine and chelerythrine as revealed by the 32P-postlabeling technique. Chem. Biol. Interact. 140, 231-242]. In our work we examined the effects of sanguinarine and chelerythrin

Czech name

Studium vlivu sanguinarinu a chelerythrinu na expresi a aktivitu CYP1A1 u lidských hepatomových buněk

Czech description

Kvarterní benzo[c]fenanthridinové alkaloidy (KBA) sanguinarin a chelerythrin vykazují široké spektrum biologických aktivit a jsou používány v přípravcích ústní hygieny. Nedávné studie ukázaly, že cytochrom P450 CYP1A snižuje toxicitu sanguinarinu in vivo(Williams, M.K., Dalvi, S., Dalvi, R.R., 2000. Influence of 3-methylcholanthrene pretreatment on sanguinarine toxicity in mice. Vet. Hum. Toxicol. 42, 196-198) a in vitro (Vrba, J., Kosina, P., Ulrichová, J., Modrianský, M., 2004. Involvement of cytochrome P450 1A in sanguinarine detoxication. Toxicol. Lett. 151, 375-387). Nicméně, CYP1A přeměňuje sanguinarin na produkty, které tvoří adukty s DNA (Stiborová, M., Šimánek, V., Frei, E., Hobza, P., Ulrichová, J., 2002. DNA adduct formation from quaternarybenzo[c]phenanthridine alkaloids sanguinarine and chelerythrine as revealed by the 32P-postlabeling technique. Chem. Biol. Interact. 140, 231-242). V naší práci jsme testovali vliv sanguinarinu a chelerythrinu na expresi CYP1A1 a katalyt

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CE - Biochemistry

OECD FORD branch

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Project

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Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2006

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Food and Chemical Toxicology

ISSN

0278-6915

e-ISSN

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Volume of the periodical

44

Issue of the periodical within the volume

2

Country of publishing house

GB - UNITED KINGDOM

Number of pages

8

Pages from-to

242-249

UT code for WoS article

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EID of the result in the Scopus database

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