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Montelukast decreases plasma endothelin-1 and serum eosinophil cationic protein levels in paediatric atopic asthma.

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F06%3A00002758" target="_blank" >RIV/61989592:15110/06:00002758 - isvavai.cz</a>

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    Montelukast decreases plasma endothelin-1 and serum eosinophil cationic protein levels in paediatric atopic asthma.

  • Original language description

    This study demonstrated a decrease in P-ET levels in children with mild asthma receiving montelukast. This indicates a reduction in the severity of the inflammatory response and, hence, provides evidence for the anti-inflammatory effect of montelukast. Monitoring both ET-1 and ECP levels at regular follow-up may be useful in assessing these two facets of activity of chronic inflammation in bronchial asthma.

  • Czech name

    Montelukast snižuje hladinu plazmatického endothelinu-1 (ET-1) a hladinu eozinofilného kationického proteinu.

  • Czech description

    ET-1 je produkován vaskulárními endotheliálními, epiteliálními buňkami, T-lymfocyty a fagocyty. Zvýšená hladina ET-1 byla prokázaná u dětských astmatických pacientů. Snížení hladin (sledovaných parametrů) u dětí s astma bronchiále po podání montelukastunepřímo potvrzuje jeho protizánětlivý účinek.

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    FN - Epidemiology, infection diseases and clinical immunology

  • OECD FORD branch

Result continuities

  • Project

  • Continuities

    Z - Vyzkumny zamer (s odkazem do CEZ)

Others

  • Publication year

    2006

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Clinical Drug Investigation

  • ISSN

    1173-2563

  • e-ISSN

  • Volume of the periodical

    26

  • Issue of the periodical within the volume

    6

  • Country of publishing house

    NZ - NEW ZEALAND

  • Number of pages

    6

  • Pages from-to

    351-356

  • UT code for WoS article

  • EID of the result in the Scopus database