Development of lung cancer before the age of 50: the role of xenobiotic

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F07%3A00003947" target="_blank" >RIV/61989592:15110/07:00003947 - isvavai.cz</a>
Result on the web
—
DOI - Digital Object Identifier
—

Result language
angličtina
Original language name
Development of lung cancer before the age of 50: the role of xenobiotic
Original language description
Objectives. The role of genes coding for xenobiotic metabolism enzymes (XME) and the risk of lung cancer is unclear. Under the assumption that these genes may be more important among people having a diagnosis of lung cancer at younger ages, we have investigated the role of single nucleotide polymorphisms (SNPs) within phase I and phase II XME genes, and also genes involved in the metabolism of nucleic acids in a series of young onset patients and matched controls. Methods. We genotyped 299 lung cancer cases diagnosed before the age of 50 and 317 controls, from six countries of Central and Eastern Europe, by use of an oligonucleotide micro-array and arrayed primer extension technique (APEX) for 45 SNPs in 15 phase I XME genes, 46 SNPs in 17 phase II genes and 9 SNPs in 4 genes related to metabolism of nucleic acids. Results. Heterozygote carriers of SNPs in CYP1A2 1545T>C, -164C>A, and -740T>G, CYP2A6 -47A>C, MDR1 3435 T>C, NAT1 1088T>A, 1095A>C, GSTA2 S112T, GSTM3 V22
Czech name
Vznik karcinomu plic u osob mladších 50 let: úloha genů xenobiotického metabolismu
Czech description
U 299 případů karcinomu plicv vzniklých před 50 rokem věku a u 317 kontrolních osob byla provedena genotypizace pro nukleotidový polymorfismus ve fázi I. a II. XME genů.

Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FN - Epidemiology, infection diseases and clinical immunology
OECD FORD branch
—

Project
<a href="/en/project/NR9029" target="_blank" >NR9029: Genetic and behavioral risk factors of pancreatic cancer - an epidemiological study.</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2007
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Similar results(10)