Protective Effects of Flavonoid Pomiferin on Heart Ischemia-Reperfusion
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F07%3A00004178" target="_blank" >RIV/61989592:15110/07:00004178 - isvavai.cz</a>
Alternative codes found
RIV/62157124:16370/07:00001101
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Protective Effects of Flavonoid Pomiferin on Heart Ischemia-Reperfusion
Original language description
The objective of the present 15-day study was to evaluate the cardioprotective potential of flavonoid pomiferin isolated from the infructences of Maclura pomifera, Moraceae, against ischemia-reperfusion induced injury in rat hearts as a model of antioxidant-based composite therapy. Studies were perfomed with isolated modified Langendorff-perfused rat hearts and ischemia of heart was initiated by stopping the coronary flow for 30 min, followed by 60 min of reperfusion (14 ml-min). Wistar rats were divided into three groups. The treated group received pomiferin (5 mg/kg/day in 5% Avicel); the placebo group received only 5% Avicel; the intact group was left without any applications. Biochemical indicators of oxidative damage, lipid peroxidation product malondialdehyde, antioxidant enzymes (superoxide dismutase, glutathione peroxidase, total antioxidant activity in serum and myocardium has been evaluated.
Czech name
Protektivní vliv flavonoidu pomiferinu na ischemii-reperfuzi srdce
Czech description
Studie se zabývá kardioprotektivním potenciálem flavonoidu pomiferinu, izolovaného z plodů Maclura pomifera, Moraceae, na modelu izolovaného perfundovaného myokardu v podmínkách ischemicko-reperfuzního poškození. Studie byla provedena na izolovaných srdcích laboratorního potkana, které byly perfundovány modifikovanou metodou dle Langendorffa. Po stabilizační, 10 minutové fázi (koronární perfuze 14 ml-min) byla navozena ischémie srdce zástavou perfuze na dobu 30 minut, poté následovala reperfuze na dobu60 minut (průtok 14 ml-min).
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FA - Cardiovascular diseases including cardio-surgery
OECD FORD branch
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Result continuities
Project
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Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2007
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Acta veterinaria Brno
ISSN
0001-7213
e-ISSN
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Volume of the periodical
76
Issue of the periodical within the volume
3
Country of publishing house
CZ - CZECH REPUBLIC
Number of pages
8
Pages from-to
363-370
UT code for WoS article
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EID of the result in the Scopus database
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