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Effects of prenylated isoflavones osajin and pomiferin in premedication on heart ischemie-reperfusion.

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16370%2F06%3A00000702" target="_blank" >RIV/62157124:16370/06:00000702 - isvavai.cz</a>

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    Effects of prenylated isoflavones osajin and pomiferin in premedication on heart ischemie-reperfusion.

  • Original language description

    The study was undertaken to evaluate the cardioprotective potential of the prenylated isoflavones osajin and pomiferin isolated from the infructences of Maclura pomifera, Moraceae, against ischemia-reperfusion induced injury in rat hearts as a model of antioxidant-based composite therapy. The study was performed on isolated, modified Langendorff-perfused rat hearts and the ischemia of heart was induced by stopping coronary flow for 30 min followed by 60 min of reperfusion (14 ml min-1). The results demonstrate that osajin and pomiferin attenuates the myocardial dysfunction provoked by ischemia-reperfusion.

  • Czech name

    Efekt prenylovaných isoflavonoidů osajinu a pomiferinu v premedikaci srdeční ischemie-reperfuze.

  • Czech description

    Studie sledovala kardioprotektivní schopnosti prenylovaných isoflavonů osajinu a pomiferinu, isolovaných z plodenství rostlin Maclura pomifera, Moraceae, proti ischemicko-reperfuznímu poškození srdce laboratorních potkanů. Experiment byl proveden na modifikovaném Langerdorffově modelu perfundovaného potkaního srdce; ischemie byla vyvolána zástavou koronárního průtoku na 30 minut, následovala 60 min reperfuze (14 ml min-1). Výsledky potvrdily, že osajin a pomiferin mírnily myokardiální dysfunkci vyvolanou ischomicko reperfuzním opškozením.

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    FR - Pharmacology and apothecary chemistry

  • OECD FORD branch

Result continuities

  • Project

  • Continuities

    S - Specificky vyzkum na vysokych skolach

Others

  • Publication year

    2006

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Biomedical Papers Faculty of Medicine of Palacky University Olomouc

  • ISSN

    1213-8118

  • e-ISSN

  • Volume of the periodical

    150

  • Issue of the periodical within the volume

    1

  • Country of publishing house

    CZ - CZECH REPUBLIC

  • Number of pages

    8

  • Pages from-to

    93-100

  • UT code for WoS article

  • EID of the result in the Scopus database