Endothelial haemostatic markers in members of families with familial combined hyperlipidemia

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F08%3A00006144" target="_blank" >RIV/61989592:15110/08:00006144 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Endothelial haemostatic markers in members of families with familial combined hyperlipidemia

Original language description

Introduction: The aim of this study was to evaluate the plasma levels of endothelial haemostatic markers - von Willebrand factor (sWF), plasminogen activator inhibitor-1 (PAI-1), tissue plasminogen activator (t-PA) and soluble thrombomodulin (sTM) - in asymptomatic, nonsmoking members of families with familial combined hyperlipidemia (FCH). We investigated the association between these factors and the intima-media thickness (IMT) of the common carotid artery, selected risk factors of atherosclerosis andmarkers of insulin resistance. Methods. 82 members of 29 FCH families were divided into two groups: HL (probands and hyperlipidemic first - degree relatives, n=47) and NL (normolipidemic first-degree relatives, n=35). The control groups C-HL (n=20) andC-NL (n=20) consisted of sex- and age-matched healthy individuals. IMT was measured by ultrasound at a far wall of both common carotid arteries. Results: Compared with healthy controls, hyperlipidemic subjects had significantly higher lev

Czech name

Endoteliální hemostatické markery u jedinců z rodin s familiární kombinovanou hyperlipidemií

Czech description

Úvod: Cílem studie bylo stanovit endoteliální hemostatické markery - von Willebrand factor (vWF), plasminogen activator inhibitor-1 (PAI-1), tissue plasminogen activator (t-PA), soluble thrombomodulin (sTM) u asymptomatických jedinců z rodin s familiárníkombinovanou hyperlipidémií (FKH). Zjišťovali jsme vztah těchto markerů k tloušťce intima-media společné karotidy (IMT), k vybraným rizikovým faktorům aterosklerózy a k markerům inzulínové rezistence. Metodika: Do prezentované studie bylo zařazeno 82 osob z 29-ti FKH rodin. Soubor byl rozdělen na hyperlipidemické jedince (HL, n=47) a normolipidemické jedince (NL, n=35). Ke skupině HL, resp. NL byla věkově a pohlavím adjustována kontrolní skupina K-HL (n=20), resp. K-NL (n=20). IMT byla měřena ultrazvukem na vzdálené stěně obou společných karotid. Výsledky: Ve srovnání se zdravými kontrolami, měli hyperlipidemičtí jedinci signifikantně vyšší hladiny vWF (146.4?73.2 % versus 112.2?29.4 %, p<0.05 ), PAI-1 (102.4[83.0-117.0] ng/ml versus 6

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FB - Endocrinology, diabetology, metabolism, nutrition

OECD FORD branch

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Project

<a href="/en/project/NR9068" target="_blank" >NR9068: Dyslipidemia classification based on concentration of apolipoprotein B and triglycerides. Association of dyslipidemic phenotypes with indices of insulin resistance, inflammation and thrombosis, subclinical and clinical atherosclerosis and DNA markers.</a><br>

Continuities

S - Specificky vyzkum na vysokych skolach

Publication year

2008

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Thrombosis Research

ISSN

0049-3848

e-ISSN

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Volume of the periodical

123

Issue of the periodical within the volume

3

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

10

Pages from-to

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UT code for WoS article

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EID of the result in the Scopus database

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