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Multiple myeloma: predictive value of Tc-99m MIBI scintigraphy and MRI in its diagnosis and therapy

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F08%3A00006148" target="_blank" >RIV/61989592:15110/08:00006148 - isvavai.cz</a>

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    Multiple myeloma: predictive value of Tc-99m MIBI scintigraphy and MRI in its diagnosis and therapy

  • Original language description

    BACKGROUND: We assessed the validity of 99mTc-MIBI scintigraphy and MRI in the diagnosis and prediction of the effect of therapy in patients with multiple myeloma (MM) and monoclonal gammopathy of unknown significance (MGUS), in whom both examinations were performed within 14 days. MATERIALS AND METHODS: Forty-seven consecutive patients with MM and 5 with MGUS were enrolled in the study. Out of 47 MM patients, 6 were in Durie-Salmon stage I and 41 had active disease in stage II or III. Fifteen patientswere examined before and within 2 months of intensive chemotherapy. Anterior and posterior whole-body scans were obtained 10 min after IV administration of 740 MBq (20 mCi) 99mTc-MIBI. MRI of Th and LS spine, T1 w.i. and STIR in the sagittal plane were performed. RESULTS: Bone marrow pathological changes in 41 MM patients with active disease were detected in 39 (95%) scintigraphic examinations and in 38 (94%) of MRI. Among 41 MM patients with active disease, 21 showed diffuse patterns of

  • Czech name

    Mnohočetný myelom: prediktivní cena Tc-99m MIBI scintigrafie a MR v jeho diagnostice a terapii.

  • Czech description

    Práce hodnotí význam 99mTc-MIBI scintigrafie a magnetické rezonance (MR) v diagnostice a predikci efektu terapie u pacientů s mnohočetným myelomem (MM) a monoklonální gamapatií nejistého významu (MGNV), u kterých byla obě vyšetření provedena v rozmezí 14dnů. Bylo vyšetřeno 47 pacientů s MM a 5 s MGNV. Závěry: 99mTc-MIBI scintigrafie a MR mají stejnou senzitivitu v detekci aktivního myelomu a jsou vzájemně komplementární. Výhodou scintigrafie je možnost celotělového vyšetření, které dovoluje lepší detekci lézí v apendikulárním skeletu a extramedulárně a rychlejší odpověď na léčbu.Výhodou MR je možnost detekce epidurálních mas a komprese obratlů.

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    FD - Oncology and haematology

  • OECD FORD branch

Result continuities

  • Project

    <a href="/en/project/NR9489" target="_blank" >NR9489: Significance of 18F-FDG PET/CT, whole body MRI and 99mTc-MIBI scintigraphy in diagnosis, clinical staging and monitoring of course of multiple myeloma</a><br>

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2008

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Nuclear Medicine Review

  • ISSN

    1506-9680

  • e-ISSN

  • Volume of the periodical

    11

  • Issue of the periodical within the volume

    1

  • Country of publishing house

    PL - POLAND

  • Number of pages

    5

  • Pages from-to

  • UT code for WoS article

  • EID of the result in the Scopus database