Multiple myeloma: predictive value of Tc-99m MIBI scintigraphy and MRI in its diagnosis and therapy
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F08%3A00006148" target="_blank" >RIV/61989592:15110/08:00006148 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Multiple myeloma: predictive value of Tc-99m MIBI scintigraphy and MRI in its diagnosis and therapy
Original language description
BACKGROUND: We assessed the validity of 99mTc-MIBI scintigraphy and MRI in the diagnosis and prediction of the effect of therapy in patients with multiple myeloma (MM) and monoclonal gammopathy of unknown significance (MGUS), in whom both examinations were performed within 14 days. MATERIALS AND METHODS: Forty-seven consecutive patients with MM and 5 with MGUS were enrolled in the study. Out of 47 MM patients, 6 were in Durie-Salmon stage I and 41 had active disease in stage II or III. Fifteen patientswere examined before and within 2 months of intensive chemotherapy. Anterior and posterior whole-body scans were obtained 10 min after IV administration of 740 MBq (20 mCi) 99mTc-MIBI. MRI of Th and LS spine, T1 w.i. and STIR in the sagittal plane were performed. RESULTS: Bone marrow pathological changes in 41 MM patients with active disease were detected in 39 (95%) scintigraphic examinations and in 38 (94%) of MRI. Among 41 MM patients with active disease, 21 showed diffuse patterns of
Czech name
Mnohočetný myelom: prediktivní cena Tc-99m MIBI scintigrafie a MR v jeho diagnostice a terapii.
Czech description
Práce hodnotí význam 99mTc-MIBI scintigrafie a magnetické rezonance (MR) v diagnostice a predikci efektu terapie u pacientů s mnohočetným myelomem (MM) a monoklonální gamapatií nejistého významu (MGNV), u kterých byla obě vyšetření provedena v rozmezí 14dnů. Bylo vyšetřeno 47 pacientů s MM a 5 s MGNV. Závěry: 99mTc-MIBI scintigrafie a MR mají stejnou senzitivitu v detekci aktivního myelomu a jsou vzájemně komplementární. Výhodou scintigrafie je možnost celotělového vyšetření, které dovoluje lepší detekci lézí v apendikulárním skeletu a extramedulárně a rychlejší odpověď na léčbu.Výhodou MR je možnost detekce epidurálních mas a komprese obratlů.
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Result continuities
Project
<a href="/en/project/NR9489" target="_blank" >NR9489: Significance of 18F-FDG PET/CT, whole body MRI and 99mTc-MIBI scintigraphy in diagnosis, clinical staging and monitoring of course of multiple myeloma</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2008
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Nuclear Medicine Review
ISSN
1506-9680
e-ISSN
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Volume of the periodical
11
Issue of the periodical within the volume
1
Country of publishing house
PL - POLAND
Number of pages
5
Pages from-to
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UT code for WoS article
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EID of the result in the Scopus database
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