Complement receptor 1 single nucleotide polymorphisms in Czech and Dutch patients with sarcoidosis

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F08%3A00006201" target="_blank" >RIV/61989592:15110/08:00006201 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Complement receptor 1 single nucleotide polymorphisms in Czech and Dutch patients with sarcoidosis

Original language description

A single nucleotide polymorphism (SNP) C5507G of the complement receptor 1 (CR1) gene has been associated with genetic susceptibility to sarcoidosis in an Italian population. In order to provide further data on the possible involvement of CR1 gene polymorphisms in sarcoidosis, CR1 SNPs C5507G and A3650G were investigated in Czech (n = 210) and Dutch (n = 116) patients with sarcoidosis with ethnically matched groups of healthy control subjects (Czech, n = 203; Dutch, n = 112). CR1 C5507G and A3650G SNPswere not associated with susceptibility to sarcoidosis or its clinical course. Further, CR1 messenger RNA expression in bronchoalveolar lavage cells investigated by quantitative reverse transcriptase?polymerase chain reaction did not differ between sarcoidosis patients and control subjects and was not associated with the presence of the CR1 5507*G allele.

Czech name

Komplementový receptor 1 jednonukleotidového polymorfismu u českých a holandských pacientů se sarkoidózou

Czech description

Jednonukleotidový polymorfismus (SNP) C5507G genu pro komplementový receptor 1 (CR1) souvisí se zvýšenou vnímavostí k sarkoidóze u italské populace. S cílem poskytnout další data o možné souvislosti polymorfismu CR1 genu a sarkoidózy byly vyšetřeny C5507G a A3650G SNPs u českých a holandských pacientů se sarkoidózou a srovnány s kontrolními subjekty. CR1 C5507G a A3650G se nepodílí na zvýšené vnímavosti k sarkoidóze ani neovlivňuje klinický průběh. Kromě toho exprese CR1 mRNA buněk bronchoalveolární laváže vyšetřovaná metodou kvantitativní RT-PCR se nelišila mezi skupinami pacientů se sarkoidózou a kontrol a nesouvisela s přítomností CR1 5507*G alely.

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EC - Immunology

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)<br>S - Specificky vyzkum na vysokych skolach

Publication year

2008

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Tissue Antigens

ISSN

0001-2815

e-ISSN

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Volume of the periodical

71

Issue of the periodical within the volume

1

Country of publishing house

DK - DENMARK

Number of pages

4

Pages from-to

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UT code for WoS article

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EID of the result in the Scopus database

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