Association of TGF-β3 and ANXA11 With Pulmonary Sarcoidosis in Greek Population
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F20%3A73601272" target="_blank" >RIV/61989592:15110/20:73601272 - isvavai.cz</a>
Alternative codes found
RIV/00098892:_____/20:N0000109
Result on the web
<a href="https://www.tandfonline.com/doi/full/10.1080/17476348.2020.1784729" target="_blank" >https://www.tandfonline.com/doi/full/10.1080/17476348.2020.1784729</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1080/17476348.2020.1784729" target="_blank" >10.1080/17476348.2020.1784729</a>
Alternative languages
Result language
angličtina
Original language name
Association of TGF-β3 and ANXA11 With Pulmonary Sarcoidosis in Greek Population
Original language description
Background In sarcoidosis, the direction and intensity of immunological reactions involved in disease pathophysiology is affected by variation in the genes coding for effector and regulatory molecules with immune functions. This study, therefore, investigates polymorphic variants in genes involved in inflammation, immune reactions, and granuloma formation in context of their plausible association with sarcoidosis, with specific focus on Greek population. Methods A total of 18 single-nucleotide polymorphisms (SNPs) were genotyped in Greek patients with pulmonary sarcoidosis (n = 103) and in healthy Greek control subjects (n = 100) using multiplexed MassARRAY (MassARRAY (R)) iPLEX assay based on MALDI-TOF mass spectrometry. ResultsTGF-beta 3 rs3917200*G variant was associated with sarcoidosis (OR: 3.04 [95% CI: 1.98-4.69],p = 2.76*10(-7)). Further,ANXA11rs1049550*A variant was associated with sarcoidosis (OR: 0.59 [0.39-0.89],p = 0.01). Conclusions This first study of genetic variation of immune-related genes in Greek patients with sarcoidosis brings to attention a novel disease 'susceptibility' factor:TGF-beta 3rs3917200*G allele. It also confirms previously reported 'protective' association between sarcoidosis and functional variantANXA11rs1049550*A. Further work is required to validate these findings and to expand investigation of their plausible relationship with clinical course of the disease.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30203 - Respiratory systems
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Expert Review of Respiratory Medicine
ISSN
1747-6348
e-ISSN
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Volume of the periodical
14
Issue of the periodical within the volume
10
Country of publishing house
US - UNITED STATES
Number of pages
5
Pages from-to
1065-1069
UT code for WoS article
000547843500001
EID of the result in the Scopus database
2-s2.0-85087841699