Detection of MMP-2 and MMP-9 in normal uncomplicated pregnancy

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F08%3A00006295" target="_blank" >RIV/61989592:15110/08:00006295 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Detection of MMP-2 and MMP-9 in normal uncomplicated pregnancy

Original language description

Backround: The invasion of extravillous trophoblast cells into the maternal endometrium is one of the key events in human placentation. The ability of these cells to infiltrate the uterine wall and to anchor the placenta to it as well as their ability toinfiltrate and adjust utero-placental vessels to pregnancy depends, among other things, on their ability to secrete enzymes that degrade the extracellular matrix. Most of these enzymes belong to the family of matrix metalloproteinases. Matrix metalloproteinases (MMPs) belong to secreted or membrane-associated zinc endopeptidases capable of digesting extracellular matrix components. This assay can be used in detecting MMP activity in biological samples using a EDANS/DABCYL fluorescence resonance energytransfer (FRET) peptide. Aim of the study: To evaluate MMP-2 and MMP-9 in healthy pregnant women Material and methods: We ascertained group of 40 women with uncomplicated pregnancy. The levels of MMP were be measured in plasma samples. Th

Czech name

Zjištění MMP-2 a MMP-9 u standardně probíhající gravidity

Czech description

Backround: The invasion of extravillous trophoblast cells into the maternal endometrium is one of the key events in human placentation. The ability of these cells to infiltrate the uterine wall and to anchor the placenta to it as well as their ability toinfiltrate and adjust utero-placental vessels to pregnancy depends, among other things, on their ability to secrete enzymes that degrade the extracellular matrix. Most of these enzymes belong to the family of matrix metalloproteinases. Matrix metalloproteinases (MMPs) belong to secreted or membrane-associated zinc endopeptidases capable of digesting extracellular matrix components. This assay can be used in detecting MMP activity in biological samples using a EDANS/DABCYL fluorescence resonance energytransfer (FRET) peptide. Aim of the study: To evaluate MMP-2 and MMP-9 in healthy pregnant women Material and methods: We ascertained group of 40 women with uncomplicated pregnancy. The levels of MMP were be measured in plasma samples. Th

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FD - Oncology and haematology

OECD FORD branch

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Project

<a href="/en/project/NR9282" target="_blank" >NR9282: The significance of endothelial markers of activation in the prediction of subsequent development of preeclampsia</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2008

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Pathophysiology of Haemostasis and Thrombosis

ISSN

1424-8832

e-ISSN

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Volume of the periodical

36

Issue of the periodical within the volume

1

Country of publishing house

CH - SWITZERLAND

Number of pages

1

Pages from-to

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UT code for WoS article

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EID of the result in the Scopus database

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