Aurora Kinases: Structure, Functions and Their Association with Cancer.

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F08%3A00007181" target="_blank" >RIV/61989592:15110/08:00007181 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Aurora Kinases: Structure, Functions and Their Association with Cancer.

Original language description

Background: Aurora kinases are a recently discovered family of kinases (A, B & C) consisting of highly conserved serinethreonine protein kinases found to be involved in multiple mitotic events: regulation of spindle assembly checkpoint pathway, functionof centrosomes and cytoskeleton, and cytokinesis. Aberrant expression of Aurora kinases may lead to cancer. For this reason the Aurora kinases are potential targets in the treatment of cancer. In this review we discuss the biology of these kinases: structure, function, regulation and association with cancer. Methods and Results: A literature search. Conclusion: Many of the multiple functions of mitosis are mediated by the Aurora kinases. Their aberrant expression can lead to the deregulation of cell division and cancer. For this reason, the Aurora kinases are currently one of the most interesting targets for cancer therapy. Some Aurora kinase inhibitors in the clinic have proven eff ectively on a wide range of tumor types. The clinical

Czech name

Aurora kinázy: struktura, funkce a jejich spojitost s rakovinou.

Czech description

Aurora kinázy jsou nedávno objevenou rodinou kináz (A, B & C) skládající se z vysoce zachovaného serin/threonin proteinových kináz, které byly nalezeny, aby byl zahrnuty v mnoha miotických záležitostech: regulace a kontrola centra růstu, průběh, funkce centrosomu a cytoskeletonu a cytokinézy.

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FD - Oncology and haematology

OECD FORD branch

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Project

<a href="/en/project/LC07017" target="_blank" >LC07017: Oncoproteomics Centre</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2008

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Biomedical Papers

ISSN

1213-8118

e-ISSN

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Volume of the periodical

152

Issue of the periodical within the volume

1

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

7

Pages from-to

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UT code for WoS article

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EID of the result in the Scopus database

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