Individual differences in the effectiveness of intracoronary high-dose bone marrow cell transplantation: capability of sestamibi SPECT/FDG PET imaging to select patients with maximum benefit from thepary

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F08%3A00007228" target="_blank" >RIV/61989592:15110/08:00007228 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Individual differences in the effectiveness of intracoronary high-dose bone marrow cell transplantation: capability of sestamibi SPECT/FDG PET imaging to select patients with maximum benefit from thepary

Original language description

Aim: We reported that autologous intracoronary mononuclear bone marrow cell (BMC) transplantation improves regional myocardial function of the infarcted wall in a dose-dependent manner (Am Heart J 2006;152:975.e9-15.). However, no previous study explained the cause of interindividual differences in the effectiveness of the cell therapy. The aim of this study was to analyse the impact of different levels of tracer uptake on improvements of left ventricular (LV) function in patients treated by high-dose cell therapy. Methods: Thirty-seven patients with irreversible damage after their first acute myocardial infarction, as confirmed by dobutamine echocardiography and sestamibi SPECT/FDG PET, underwent BMC transplantation (1 x 108 cells), whereas 36 similarpatients were randomly integrated into a control group. Results: In 16 BMCtreated patients with very low sestamibi uptake at less than 30% of maximum in the infarcted area, the mean left-ventricular ejection fraction

Czech name

Individuální rozdíly v efektivitě intrakoronární transplantace vyšší dávky buněk kostní dřeně: schopnost sestamibi SPECT/FDG PET zobrazení určit pacienty s maximálním prospěchem z terapie

Czech description

Cíl: V předchozí práci jsme referovali o závislosti úpravy funkce v infarktovém ložisku na aplikované dávce autologních buněk kostní dřeně při jejich intrakoronarní transplantaci

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FA - Cardiovascular diseases including cardio-surgery

OECD FORD branch

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Project

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Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2008

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

European Journal of Nuclear Medicine and Molecular Imaging

ISSN

1619-7070

e-ISSN

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Volume of the periodical

35

Issue of the periodical within the volume

2

Country of publishing house

DE - GERMANY

Number of pages

1

Pages from-to

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UT code for WoS article

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EID of the result in the Scopus database

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