Changes in biomechanical parameters during heart perfusion and after midazolam pre-medication-experimental pilot study
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F08%3A00007242" target="_blank" >RIV/61989592:15110/08:00007242 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Changes in biomechanical parameters during heart perfusion and after midazolam pre-medication-experimental pilot study
Original language description
Background: Midazolam is a frequently used benzodiazepine in anaesthesiology and intensive care. Aim: The aim of pilot study was to monitor its effect during heart perfusion in the laboratory rat. Methods: The same groups of animals (n = 10). The 1 st group was treated with midazolam in a dose of 0.5 mg/kg i.p. The 2nd group was a placebo. After i.p. administration of heparine injection of 500 IU dose, the hearts were excised and perfused (modified Langendorf's method). Working schedule: stabilization/ischaemia/reperfusion proceed at intervals of 20/30/60 min. Monitored parameters in isolated heart: left ventricle pressure (LVP), end-diastolic pressure (LVEDP), contractility (+dP/dt max).
Czech name
Změny biomechanických ukazatelů po premedikaci midazolamem v průběhu srdeční eschémie-reperfuze - experimentální pilotní studie
Czech description
Cílem studie bylo monitorovat efekt midazolamu za podmínek eschémie-reperfuze myokardu laboratorního potkana. Na základě prezentovaných výsledků byl zjištěn pozitivní efekt testované látky na změny systolického a end-diastolického tlaku a dále návrat kontraktility v normohodnotám. Domníváme se, že midazolam má kardioprotektivní potenciál.
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FA - Cardiovascular diseases including cardio-surgery
OECD FORD branch
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Result continuities
Project
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Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2008
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Biomedical Papers
ISSN
1213-8118
e-ISSN
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Volume of the periodical
152
Issue of the periodical within the volume
1
Country of publishing house
CZ - CZECH REPUBLIC
Number of pages
4
Pages from-to
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UT code for WoS article
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EID of the result in the Scopus database
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