Epidermal Growth Factor Receptor as a Predictor of Tumor Response to Preoperative Chemoradiation in Locally Advanced Gastric Carcinoma

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F08%3A00007457" target="_blank" >RIV/61989592:15110/08:00007457 - isvavai.cz</a>

Alternative codes found

RIV/61989592:15110/08:00007576 RIV/00179906:_____/08:00001159 RIV/00216208:11150/08:00106944

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Epidermal Growth Factor Receptor as a Predictor of Tumor Response to Preoperative Chemoradiation in Locally Advanced Gastric Carcinoma

Original language description

The purpose of our study was a retrospective evaluation whether the intensity of epidermal growth factor receptor (EGFR) expression predicts tumor response to preoperative chemoradiotherapy in patients with locally advanced gastric carcinoma. Thirty-sixpatients with gastric adenocarcinoma (cT2-4 or N+) were studied. Preoperative treatment consisted of 30-45 Gy of gastric irradiation with continuous 5-fluorouracil and weekly cisplatin. Surgical resection was performed 4-6 weeks later. EGFR expression inpretreatment tumor biopsies was assessed by immunohistochemistry. Level of EGFR expression was determined from the intensity and extent of staining. Tumor response was defined as a reduction of at least one T-stage level and/or finding of intense tumorregression in histopathologic examination. Seventeen patients responded to preoperative chemoradiation - 8 patients (22%) had pathologic complete response, 9 patients (25%) were downstaged. Positive EGFR expression was found in 8 tumors (

Czech name

Epidermální růstový receptorový faktor jako prediktor tumor ové odpovědi na preoperační chemoradiaci v lokální rakoviny střev

Czech description

Cílem této studie bylo retrospektivně evaluovat, zdali intenzita epidermálního růstového faktoru receceptorové (EGFR) exprese predikuje odpověď nádoru na preopertaivní chemoterapii u pacinetů s lokálním karcinomem střev.

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FD - Oncology and haematology

OECD FORD branch

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Project

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Continuities

S - Specificky vyzkum na vysokych skolach

Publication year

2008

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

STRAHLENTHERAPIE UND ONKOLOGIE

ISSN

0179-7158

e-ISSN

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Volume of the periodical

184

Issue of the periodical within the volume

11

Country of publishing house

DE - GERMANY

Number of pages

6

Pages from-to

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UT code for WoS article

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EID of the result in the Scopus database

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