Expression of p53, p21 and p16 does Nor Correlate with Response to Preoperative Chemoradiation in Gastric Carcinoma

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F09%3A10223889" target="_blank" >RIV/61989592:15110/09:10223889 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Expression of p53, p21 and p16 does Nor Correlate with Response to Preoperative Chemoradiation in Gastric Carcinoma

Original language description

A retrospective evaluation was oerformed to determine whether the intensity of p53, p21 or p16 expression predicts response to preoperative chemoradiotherapy in locally advanced gastric carcinoma. Methodology: Thirty-six patients (cT2-4 or N+) were studied. Preoperative treatment consisted of 30-45Gy of radiation with continuous 5-fluorouracil and weekly cisplatin. Expression of p53, p21 and p16 in pretreatment biopsies was assessed by immunohistochemistry. Level of expression was determined from the intensity and extent of staining. Tumor downstaging was defined as a reduction of at least one T-stage level and/or finding of intense tumor regression in histopathologic examination.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FD - Oncology and haematology

OECD FORD branch

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Project

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Continuities

S - Specificky vyzkum na vysokych skolach

Publication year

2009

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

H.G.E. Update Medicial Publishing S.A. Athens-Stuttgart

ISSN

0172-6390

e-ISSN

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Volume of the periodical

2009

Issue of the periodical within the volume

56

Country of publishing house

GR - GREECE

Number of pages

6

Pages from-to

1213-1218

UT code for WoS article

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EID of the result in the Scopus database

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