Influence of gender on the course of neuromuscular block following a single bolus dose of cisatracurium or

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F08%3A10224454" target="_blank" >RIV/61989592:15110/08:10224454 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Influence of gender on the course of neuromuscular block following a single bolus dose of cisatracurium or
Original language description
Background: There is increasing evidence of gender differences in the pharmacokinetics of aminosteroid neuromuscular blocking agents. Compared to males, females are more susceptible, requiring approximately 30% less rocuronium to achieve the same degreeof neuromuscular block. Methods: In all, 848 patients undergoing general surgery under total intravenous anesthesia with muscle relaxation, tracheal intubation and mechanical ventilation were studied. Conclusion: Females were more sensitive than males toa single bolus dose of rocuronium. Under study conditions described, the onset tume was shorter and the clinical duration was increased in female patients.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
AA - Philosophy and religion
OECD FORD branch
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Publication year
2008
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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