PRUNELLA VULGARIS EXTRACT AND ROSMARINIC ACID SUPPRESS LIPOPOLYSACCHARIDE-INDUCED ALTERATION IN HUMAN GINGIVAL FIBROBLASTS

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F09%3A00009496" target="_blank" >RIV/61989592:15110/09:00009496 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
PRUNELLA VULGARIS EXTRACT AND ROSMARINIC ACID SUPPRESS LIPOPOLYSACCHARIDE-INDUCED ALTERATION IN HUMAN GINGIVAL FIBROBLASTS
Original language description
Periodontitis is a chronic disease associated with inflammation of the tooth-supporting tissues. The inflammation is initiated by a group of gram-negative anaerobic bacteria. These express a number of irritating factors including a lipopolysaccharide (LPS), which plays a key role in periodontal disease development. Plant extracts with anti-inflammatory and anti-microbial properties have been shown to inhibit bacterial plaque formation and thus prevent chronic gingivitis. In this study we tested effectsof Prunella vulgaris L. extract (PVE; 5, 10, 25 ?g/ml) and its component rosmarinic acid (RA; 1 ?g/ml) on LPS-induced oxidative damage and inflammation in human gingival fibroblasts. PVE and RA reduced reactive oxygen species (ROS) production, intracellular glutathione (GSH) depletion as well as lipid peroxidation in LPS-treated cells. Treatment with PVE and RA also inhibited LPS-induced up-regulation of interleukin 1? (IL-1?), interleukin 6 (IL-6), tumor necrosis factor-? (TNF) and supp
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CE - Biochemistry
OECD FORD branch
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Publication year
2009
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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