Polyphenolic fraction of Lonicera caerulea L. fruits reduces oxidative stress and inflammatory markers induced by lipopolysaccharide in gingival fibroblasts

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F10%3A10213260" target="_blank" >RIV/61989592:15110/10:10213260 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Polyphenolic fraction of Lonicera caerulea L. fruits reduces oxidative stress and inflammatory markers induced by lipopolysaccharide in gingival fibroblasts

Original language description

The most common oral diseases have a microbial aetiology. Pathogenic bacteria liberate a number of irritating agents including a lipopolysaccharide (LPS) that activates pro-inflammatory cytokines promoting increased activity of polymorphonucleocytes (PMN). Berries of Lonicera caerulea L. are rich in phenolic acids, flavonoids and anthocyanins that have multiple biological activities in vitro and in vivo. Studies have shown that polyphenols suppress a number of LPS-induced signals. We assessed effects ofthe polyphenolic fraction of L. caerulea fruits (PFLC; 77% anthocyanins) on LPS-induced oxidative damage and inflammation in human gingival fibroblasts. PFLC (10-50mug/ml) reduced reactive oxygen species production, intracellular glutathione depletion and lipid peroxidation in LPS-treated cells. PFLC treatment also inhibited LPS-induced up-regulation of interleukin-1beta, interleukin-6 and tumour necrosis factor-alpha and it suppressed expression of cyclooxygenase-2.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CE - Biochemistry

OECD FORD branch

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Project

<a href="/en/project/FT-TA3%2F024" target="_blank" >FT-TA3/024: Plant chemoprotectants - New food supplements for health and prevention of chronic diseases.</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2010

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Food and Chemical Toxicology

ISSN

0278-6915

e-ISSN

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Volume of the periodical

48

Issue of the periodical within the volume

6

Country of publishing house

GB - UNITED KINGDOM

Number of pages

7

Pages from-to

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UT code for WoS article

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EID of the result in the Scopus database

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