Antibodies against complement system in SLE and their potential diagnostic utility

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F09%3A00009789" target="_blank" >RIV/61989592:15110/09:00009789 - isvavai.cz</a>

Result on the web

—

DOI - Digital Object Identifier

—

Result language

angličtina

Original language name

Antibodies against complement system in SLE and their potential diagnostic utility

Original language description

SLE is characterized by overproduction of various types of antibodies. Under certain circumstances, antibodies aiming some of the neoepitopes of the complement system can be seen. Neoepitopes are not present in the native proteins, but they appear afterthe structural change of the complement system. One of these antibodies binds the activated product C3 called iC3b+ however, its possible part in the pathogenesis of a disease is unknown. Some of the antibodies to the component of the complement system are more significant. One of them is the C3 nephritic factor connected with partial lipodystrophy and with a certain form of mesangial glomerulonephritis. This factor also rarely appears in patients with SLE. Another antibody targets the C1 inhibitor andappears in some patients with lymphomas. Anti-C1q antibodies are present in approximately one third of the patients with lupus, who often have high clinical activity of the disease, and particularly, renal involvement. In the presence of

Czech name

—

Czech description

—

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FE - Other fields of internal medicine

OECD FORD branch

—

Project

<a href="/en/project/NR8406" target="_blank" >NR8406: Prognostic importance of hypocomplementemia for the type and clinical manifestation of lupus nephritis</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2009

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Current Rheumatology Reviews

ISSN

1573-3971

e-ISSN

—

Volume of the periodical

5

Issue of the periodical within the volume

1

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

6

Pages from-to

—

UT code for WoS article

—

EID of the result in the Scopus database

—