Capillary electrophoresis determination of thiopurine methyl transferase activity in erythrocytes
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F09%3A33138354" target="_blank" >RIV/61989592:15110/09:33138354 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1016/j.jchromb.2009.05.005" target="_blank" >http://dx.doi.org/10.1016/j.jchromb.2009.05.005</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.jchromb.2009.05.005" target="_blank" >10.1016/j.jchromb.2009.05.005</a>
Alternative languages
Result language
angličtina
Original language name
Capillary electrophoresis determination of thiopurine methyl transferase activity in erythrocytes
Original language description
Thiopurine S-methyltransferase (TPMT) catalyzes methylation of thiopurine drugs (e.g. 6-mercaptopurine, azathioprine). Decreased activity of TPMT is associated with hematopoietic toxicity after administration of standard doses of the drugs. We developedcapillary electrophoretic method for determination of TPMT enzyme activity in erythrocytes. Limit of quantification of the method is 1.5 micromol/L (S/N=6). The recovery of 6-methylmercaptopurine was 87.5-94.8%, imprecision value (as CV, n=10) was 1.68%(within-day) and 2.53% (between-day). Erythrocyte TPMT activities were measured in 60 healthy adult volunteers
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CB - Analytical chemistry, separation
OECD FORD branch
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Result continuities
Project
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Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2009
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
ISSN
1570-0232
e-ISSN
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Volume of the periodical
877
Issue of the periodical within the volume
20-21
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
3
Pages from-to
1943-1945
UT code for WoS article
000267453800022
EID of the result in the Scopus database
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