Neutrophilic differentiation modulates the apoptotic response of HL-60 cells to sodium butyrate and sodium valproate

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F10%3A10213258" target="_blank" >RIV/61989592:15110/10:10213258 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Neutrophilic differentiation modulates the apoptotic response of HL-60 cells to sodium butyrate and sodium valproate
Original language description
We examined whether HL-60 cells differentiating by all-trans retinoic acid (ATRA) acquired resistance to apoptotic activity of butyrate and valproate. In undifferentiated cells, cytotoxicity of butyrate and valproate was associated with activation of intrinsic apoptotic pathway since we observed dissipation of mitochondrial potential, activation of caspase-9 and -3, appearance of sub-G1 DNA and loss of plasma membrane asymmetry and/or integrity. Both compounds also induced accumulation of undifferentiated cells in G0/G1 phase of cell cycle. ATRA enhanced the apoptotic effect of both butyrate and valproate in undifferentiated cells. This aside, ATRA synergized with butyrate in the induction of G0/G1 arrest. In cells pretreated for 72 h with ATRA, butyrate and valproate in combination with ATRA induced lower dissipation of mitochondrial membrane potential and weaker apoptotic and/or necrotic changes in plasma membrane, whereas DNA fragmentation was not diminished compared to undifferenti
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CE - Biochemistry
OECD FORD branch
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Publication year
2010
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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