Array comparative genomic hybridization in the detection of chromosomal abnormalities in T-cell prolymphotic leukemia

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F10%3A10213576" target="_blank" >RIV/61989592:15110/10:10213576 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Array comparative genomic hybridization in the detection of chromosomal abnormalities in T-cell prolymphotic leukemia
Original language description
Array comparative genomic hybridization and fluorescence in situ hybridization help in reevaluating and filling out the pattern of chromosomal rearrangement in T-cell prolymphocytic leukemia. In T-PLL, the karyotype is usually complex and characterized by the presence of multiple chromosomal changes involving T-cell receptor ? a ?(TCR ?/?). Recurring chromosomal aberration include inversion or translocation involving TCL1. In two cases with failed G-banding chromosome analysis we detected genomic imbalances by array CGH in both cases. Derivate chromosome 14 was found in both of T-PLL cases. These findings confirm the importance of precise molecular karyotype determination in patients diagnosed with T-PLL.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Project
<a href="/en/project/NR9484" target="_blank" >NR9484: High throughput detection of genetic alterations in chronic lymphocytic leukemia using array comparative genomic hybridization</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2010
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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