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Array comparative genomic hybridization in the detection of chromosomal abnormalities in T-cell prolymphotic leukemia

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F10%3A10213576" target="_blank" >RIV/61989592:15110/10:10213576 - isvavai.cz</a>

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    Array comparative genomic hybridization in the detection of chromosomal abnormalities in T-cell prolymphotic leukemia

  • Original language description

    Array comparative genomic hybridization and fluorescence in situ hybridization help in reevaluating and filling out the pattern of chromosomal rearrangement in T-cell prolymphocytic leukemia. In T-PLL, the karyotype is usually complex and characterized by the presence of multiple chromosomal changes involving T-cell receptor ? a ?(TCR ?/?). Recurring chromosomal aberration include inversion or translocation involving TCL1. In two cases with failed G-banding chromosome analysis we detected genomic imbalances by array CGH in both cases. Derivate chromosome 14 was found in both of T-PLL cases. These findings confirm the importance of precise molecular karyotype determination in patients diagnosed with T-PLL.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    FD - Oncology and haematology

  • OECD FORD branch

Result continuities

  • Project

    <a href="/en/project/NR9484" target="_blank" >NR9484: High throughput detection of genetic alterations in chronic lymphocytic leukemia using array comparative genomic hybridization</a><br>

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2010

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Cancer Genetics and Cytogenetics

  • ISSN

    0165-4608

  • e-ISSN

  • Volume of the periodical

    202

  • Issue of the periodical within the volume

    1

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    5

  • Pages from-to

  • UT code for WoS article

  • EID of the result in the Scopus database