Differential expression of ABC transporters ( MDR1, MRP1, BCRP) in developing human embryos
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F11%3A10223785" target="_blank" >RIV/61989592:15110/11:10223785 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1007/s10735-011-9363-1" target="_blank" >http://dx.doi.org/10.1007/s10735-011-9363-1</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s10735-011-9363-1" target="_blank" >10.1007/s10735-011-9363-1</a>
Alternative languages
Result language
angličtina
Original language name
Differential expression of ABC transporters ( MDR1, MRP1, BCRP) in developing human embryos
Original language description
Three ABC transporters (MDR1, MRP1, BCRP), belonging to the family of multidrug resistence (MDR) proteins, play a crucial role in the protection mechanisms during embryogenesis and mediate drug resistance in cancer cells. The distribution of these transporters in the series of human embryonal/fetal intestine, liver and kidneys of various stages of intrauterine development (IUD) by indirect two-step immunohistochemical method was investigated.The organ-and age-specific expression patterns of these transporters were depicted and compared with the expression in adult organs.The evaluation of intestine and liver samples demonstrate differences in expression pattern of ABC transporters during IUD. On the contrary, in kidneys the age-specific localization was not observed. However, the increasing positivity from the kidney surface towards deeper, more differentiated parts was found. Hopefully, our study may contribute to elucidation of the role of multidrug resistance (MDR) pathways during I
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
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Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Molecular Histology
ISSN
1567-2379
e-ISSN
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Volume of the periodical
42
Issue of the periodical within the volume
6
Country of publishing house
DE - GERMANY
Number of pages
8
Pages from-to
567-574
UT code for WoS article
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EID of the result in the Scopus database
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