Differential expression of ABC transporters ( MDR1, MRP1, BCRP) in developing human embryos

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F11%3A10223785" target="_blank" >RIV/61989592:15110/11:10223785 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1007/s10735-011-9363-1" target="_blank" >http://dx.doi.org/10.1007/s10735-011-9363-1</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s10735-011-9363-1" target="_blank" >10.1007/s10735-011-9363-1</a>

Result language

angličtina

Original language name

Differential expression of ABC transporters ( MDR1, MRP1, BCRP) in developing human embryos

Original language description

Three ABC transporters (MDR1, MRP1, BCRP), belonging to the family of multidrug resistence (MDR) proteins, play a crucial role in the protection mechanisms during embryogenesis and mediate drug resistance in cancer cells. The distribution of these transporters in the series of human embryonal/fetal intestine, liver and kidneys of various stages of intrauterine development (IUD) by indirect two-step immunohistochemical method was investigated.The organ-and age-specific expression patterns of these transporters were depicted and compared with the expression in adult organs.The evaluation of intestine and liver samples demonstrate differences in expression pattern of ABC transporters during IUD. On the contrary, in kidneys the age-specific localization was not observed. However, the increasing positivity from the kidney surface towards deeper, more differentiated parts was found. Hopefully, our study may contribute to elucidation of the role of multidrug resistance (MDR) pathways during I

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EB - Genetics and molecular biology

OECD FORD branch

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Project

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Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2011

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Molecular Histology

ISSN

1567-2379

e-ISSN

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Volume of the periodical

42

Issue of the periodical within the volume

6

Country of publishing house

DE - GERMANY

Number of pages

8

Pages from-to

567-574

UT code for WoS article

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EID of the result in the Scopus database

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