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Differential expression of ABC transporters ( MDR1, MRP1, BCRP) in developing human embryos

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F11%3A10223785" target="_blank" >RIV/61989592:15110/11:10223785 - isvavai.cz</a>

  • Result on the web

    <a href="http://dx.doi.org/10.1007/s10735-011-9363-1" target="_blank" >http://dx.doi.org/10.1007/s10735-011-9363-1</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1007/s10735-011-9363-1" target="_blank" >10.1007/s10735-011-9363-1</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Differential expression of ABC transporters ( MDR1, MRP1, BCRP) in developing human embryos

  • Original language description

    Three ABC transporters (MDR1, MRP1, BCRP), belonging to the family of multidrug resistence (MDR) proteins, play a crucial role in the protection mechanisms during embryogenesis and mediate drug resistance in cancer cells. The distribution of these transporters in the series of human embryonal/fetal intestine, liver and kidneys of various stages of intrauterine development (IUD) by indirect two-step immunohistochemical method was investigated.The organ-and age-specific expression patterns of these transporters were depicted and compared with the expression in adult organs.The evaluation of intestine and liver samples demonstrate differences in expression pattern of ABC transporters during IUD. On the contrary, in kidneys the age-specific localization was not observed. However, the increasing positivity from the kidney surface towards deeper, more differentiated parts was found. Hopefully, our study may contribute to elucidation of the role of multidrug resistance (MDR) pathways during I

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    EB - Genetics and molecular biology

  • OECD FORD branch

Result continuities

  • Project

  • Continuities

    Z - Vyzkumny zamer (s odkazem do CEZ)

Others

  • Publication year

    2011

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Journal of Molecular Histology

  • ISSN

    1567-2379

  • e-ISSN

  • Volume of the periodical

    42

  • Issue of the periodical within the volume

    6

  • Country of publishing house

    DE - GERMANY

  • Number of pages

    8

  • Pages from-to

    567-574

  • UT code for WoS article

  • EID of the result in the Scopus database